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10 Cards in this Set
- Front
- Back
Epinephrine (Adrenalin) |
Adrenergic agonist, sympathomimetic, catecholamine MOA: stimulates alpha1, beta1, & beta 2 adrenergic receptors Effects: alpha1 - ↑ blood pressure beta1 - cardiac stimulation beta2 - promotes bronchodilation (relaxation), vasodilation of skeletal muscle vasculature *undergoes enzymatic inactivation by monoamine oxidase (MAO) in the liver |
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Dopamine |
Adrenergic agonist, catecholamine, sympathomimetic, vasopressor MOA: stimulates alpha1, beta1, & dopaminergic receptors Effects: acts on renal nephrons (autocrine/paracrine) low doses - dopaminergic receptors; dilates renal & mesenteric vasculature, ↑ renal perfusion, ↑ UO moderate doses - dopaminergic & beta; ↑ HR, ↑ contractility, ↑ CO high doses - all 3 receptors; peripheral vasoconstriction, ↑ BP |
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albuterol (Proventil) |
Sympathomimetic, beta2 adrenergic agonist MOA: selective beta 2 receptors Effects: bronchodilation; ↑ diffusion & perfusion, ↑ blood O2 * many adverse effects, more common when administered PO than INH |
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phenylephrine (neo-synephrine) |
Selective alpa1 adrenergic agonist, sympathomimetic, decongestant MOA: alpha adrenergic receptors on nasal blood vessels to cause shrinkage of swollen membranes & local arterial vasoconstriction Effects: nasal decongestion, ↑ BP (for IV) *typically given topically for nasal decongestion, causes rapid and intense response |
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propranolol (Inderal) |
non-selective beta-adrenergic antagonist, adrenergic antagonist, beta-blocker, antihypertensive MOA: blocks beta1 & 2 receptors Effects: ↓ sympathetic outflow to periphery and suppress RAAS ↓ BP, ↓ HR, ↓ force of contraction, ↓ CO, ↓ glycogenolysis *Boxed Warning: beta-blocker therapy should not be stopped abruptly |
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phentolamine (Oraverse) |
alpha1 blocker, alpha1 adrenergic antagonist MOA: competitively blocks alpha1-adrenergic receptors Effects: brief antagonism of circulation Epi and norEpi; controls BP *used to treat pheochromocytoma & prevent tissue necrosis |
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prazosin (Minipress) |
alpha1 blocker, selective alpha1-adrenegrcic antagonist, antihypertensive MOA: selective blockade of alpha1 adrenergic receptors by competing with norEpi on vascular smooth muscle Effects: vasodilation, ↓ BP |
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bethanechol (Urecholine) |
cholinergic agonist, parasympathetic agent, muscarine agonsit MOA: acts on muscarinic receptors in heart, exocrine glands, & smooth muscle (bladder) Effects: contraction of the detrusor muscle & relaxation of the external sphincter, micturation * used to treat non-obstructive urinary retention, antidote = atropine |
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atropine |
anticholinergic, parasympatholytic, muscarinic cholinergic receptor anatagonist MOA: competes w/ ACh for binding sites on muscarinic receptors on cardiac/smooth muscle & exocrine glands Effects: blocks muscarinic effects, ↓ GI motility, ↓ secretory activity (↓ saliva & bronchial secretions), ↓ GU muscle tone, ↑ HR, ophthalmic mydriasis *OD by any muscarinic agonist, antidote for organosphosphate poisoning *Anticholinergic crisis : mad as a hatter, dry as a bone; red as a beet, hot as a hare; blind as a bat |
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tolterodine (detrol) |
anticholinergic, antimuscarinic, nonselective muscarinic antagonist MOA: antimuscarinic activity (mostly on bladder) Effects: relaxes urinary bladder, ↓ urinary frequency & urgency *used to treat overactive bladder syndrome |