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43 Cards in this Set
- Front
- Back
Functions of the different RNA polymerases I, II and III?
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I,II,II = R.M.T
(rRNA, mRNA, and tRNA) |
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Name the stop codons?
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UGA = U Go Away
UAA = U Are Away UAG = U Are Gone |
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What are the functions of the Golgi apparatus?
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Su.Pro.Dis.N.O.Man. !
Sulfation of sugars in proteoglycans and tyrosine Proteoglycan assembly Distribution center of proteins and lipids N-oligosacc. modification on Asn O-oligosacc. addition to serine and threonine Mannose-6-Phophate addition to lysosomal proteins |
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Collagen types?
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B.e C.ool R.ead B.ooks
Bone Cartilage Reticulin Basement membrane Type X - epiphyseal plate |
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What is S-adenosylmethionine?
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SAM the methyl donor man
(SAM regeneration is dependent on B12) |
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The TCA cycle intermediates, starting from Citrate....?
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C.an I. K.eep S.elling S.ex F.or M.oney O.fficer?
Citrate Isocitrate (alpha)-Ketoglutarate Succinyl CoA Succinate Fumarate Malae Oxaloacetate |
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Name the enzymes responsible for gluconeogenesis?
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P.athway P.roduces F.resh G.lucose
Pyruvate carboxylase (mitochondria, the rest are cytosolic) PEP carboxykinase Fructose-1,6 bisphosphatase Glucose-6-phosphatase |
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G6PD deficiency?
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5H's - .
HMP shunt enzyme deficiency Hurts RBCs by exposing them to oxidation, which normally is prevented by NADPH Hemoglobin is altered, precipitates Heinz bodies form Hemolytic anemia results |
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Name the essential amino acids?
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P.v.t. T.I.M. H.A.L.L.
Phe Val Thr Typ Ile Met His Arg Leu Lys |
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Name the components (intermediates and enzymes) of the urea cycle
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O.rdinarily, C.areless C.rappers A.re A.lso F.rivolous A.bout U.rination
Ornithine Carbamoyl phosphate Citrulline Aspartate Argininosuccinate Fumarate Arginine Urination |
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Cystinuria is caused by a defect of...?
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Renal tubular amino acid transporter for C.O.L.A.
Cystine Ornithine Lysine Arginine |
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Maple Syrup Urine disease?
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Blocked degradation of branched amino acids (Ile, Val, Leu)
I. L.ove V.ermont Maple Syrup |
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Lesch-Nyhan syndrome?
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L.N.S. = Lacks Nucleotide Salvage (purine)
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What does the liver do generally during the fasting state?
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"In the Phasting state, Phosphorylate."
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Which tissues don't need insulin for glucose uptake?
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BRICK L:
Brain RBCs Intestine Cornea Kidney Liver |
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What are the anabolic affects of insulin?
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Gluck Sometimes Tries to Glide Professionally
Increased: Glucose transport Sodium retention by kidneys Triglyceride snythesis and storage Glycogen synthesis and storage Protein synthesis by the muscles |
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Pompe's?
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"Pompe's trashes the Pump"
(heart, liver, and muscle) Glycogen storage disease |
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Name the glycogen storage diseases?
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V.ery P.oor C.arbohydrate M.etabolism
Von Gierke's Pompe's Cori's McArdle's |
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Niemann-Pick?
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"NO MAN PICKS his nose with his SHPINGER" (shpingomyelinase)
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Tay Sachs?
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Tay SaX laX heXosaminidase
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Hunter's?
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"HUNTERS aim for the X" (X recessive
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What are the major apolipoproteins and what do they do?
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A-1 Activates LCAT
B-100 Binds to LDL receptor C-II Cofactor for lipoprotein lipase E - mEdiates Extra (remnant) uptake |
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Symptoms of porphyrias?
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5P's -
Painful abdomen Pink urine Polyneuropathy Psychological disturbances Precipitated by drugs |
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How to treat methemoglobinemia?
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"Treat toxic levels of METHemoglobin with METHylene blue"
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Imprinting: Angelman's and Prader-Willi syndrome?
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AngelMAN's and P.rader-Willi (P.aternal)
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Duchenne's - the molecular problem?
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Deleted dystrophin
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Trinucleotide repeat expansion diseases?
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"Try hunting for my fried eggs."
Try - trinucleotide Hunting.ton's disease My.otonic dystrophy Fried.reich's ataxia Eggs (Fragile X syndrome) |
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Fragile X syndrome?
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Xtra-large testes, jaw, ears
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Edward's syndrome: what causes it?
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Election age = 18
T.risomy 18 |
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Patau's syndrome: what causes it?
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Trisomy 13
P.uberty = 13 |
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Cri-du-chat?
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CRI D.U. C.H.A.T
Dumb - mental retardation Underdeveloped brain - microcephaly Cardiac abnormalities Hypertelorism "Asian eyes" - epicanthal folds Terminal deletion - of 5p |
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22q11 syndromes
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CATCH 22
Cleft palate Abnormal facies Thymic aplasia --> T cell deficiency Cardiac defects Hypocalcemia secondary to parathyroid aplasia |
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Vitamin A is aka?
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Retinol (think RetinA)
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Beriberi?
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Ber1Ber1 - Vitamin B1 deficiency
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Wernicke-Korsakoff?
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Were you drinking
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Vitamin B2... aka? Deficiency causes?
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I C.an S.ense C.razy F.lavor
FAD and FMN are derived from RiboFlavin Cheilosis Stomatitis (angular) Corneal vascularization |
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Vitamin B3?
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"B.e Ni.ce, or you'll get Pellagra"
3D's - Diarrhea Dermatitis Dementia Dreadful tongue (beefy glossitis) |
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Biotin?
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AVIDIN in egg whites
AVIDly binds biotin |
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Vitamin E
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"E is for Erythrocytes"
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Vitamin K
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"K for Koagulation"
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Kwashiorkor?
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Protein-deficient MEAL:
Malabsorption Edema Anemia Liver (fatty) |
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G protein linked 2nd messengers via phospholipase C?
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H.A.V. 1 M & M
H1 a1 V1 M1 M3 |
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G protein linked 2nd messengers via Adenylyl cyclase?
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MAD 2s
M2 a2 D2 (via Gi) [the others in this group operate via Gs] |