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150 Cards in this Set

  • Front
  • Back

Each receptor cell monitors

A specific area known as a receptive field

Referred pain

Sensors originating in visceral organs are perceived as pain in other body regions innervated by the same spinal nerves

Tactile receptor

A sensory nerve ending that responds to various stimuli including light and touch

What are the 6 tactile receptors

Free nerve endings


A root hair plexus


Merkels disks and cells


Meissners corpuscle


Lamellated corpuscle


A Ruffini corpuscle

Baroreceptors....their 4 locations and purposes

Sensors located in blood vessels that sense blood pressure and relay info to the brain so that a proper blood pressure can be maintained.



Also are located in the digestive tract to trigger reflex movement of materials along the tract



Also located in the bladder wall to provide info on volume and trigger urinary reflex



Also located in the lungs to monitor respiratory rate and stretching


Chemoreceptors

A sensory receptor that transducer a chemical signal into an action potential. Detects chemical stimuli in the env.



2 classes:


Direct: taste buds


Distance: olfactory

Olfactory receptor

A modified neuron with multiple cilia extending from its free surface.



Cilia detect smell -> olfactory cell -> olfactory nerve fibers -> olfactory bulb

Regenerative basal cell

Divides to replace worn out olfactory receptor cells

Olfactory epithelium

Contains olfactory receptor cells and olfactory glands

Gustatory receptors

Detects taste. Inside taste buds which form pockets along the sides of epithelial projections called papillae

Pupillary muscles

Two sets of intrinsic smooth muscle within the iris control the diameter of the pupil. Bright light concentric muscles contract to reduce the level of incoming light. Dim light: radial muscles contract to dilate the pupil

Aqueous humor

Secreted by the ciliary body circulates through the posterior and anterior chambers. Lens position maintained by suspensory ligaments

The closer the light source

The longer the focal distance

The rounder the lens

The shorter the focal distance

What eye muscle contracts or relaxrs to control distance

Ciliary muscle



Contract = lens rounds = close vision


Relax = lens flattens = distant vision

What affects focal distance

Location of light source.


Lens shape

Image formation

Light from each portion of an object is focused on a different part of the retina. The resulting image is upside down and backwards

Rods and cones

The shapes of the photoreceptors outer segment. Their membrane discs contain the visual pigments, which are derived from rhodopsin molecules

Movement of light in the eye

Light - bipolar cell - cone/rod in inner segment - discs with visual pigment in outer segment to pigment epithelium

Visual association areas

In the cerebrum integrate the visual information to develop a composite picture of the entire visual field.



Eye - optic nerve - brain

Otolith in the ear

In the inner ear vestibular complex.


Sensitive to gravity and linear acceleration because their orientation in the head makes it sensitive to change in horizontal movement.



When the otolith moves, it distorts hair cell processes and receptor output increases

Cochlea

The sense organ in the inner ear that translates sound to nerve impulses to be sent to the brain. Fluid filled and snail shaped cavern

6 steps in sound reception

1. Waves arrive at tympanic membrane


2. Movement of tympanic membrane moves auditory ossicles


3. Movement of staples at oval window makes pressure waves in vestibular duct


4. Pressure waves distort basilar membrane


5. Causes vibration or hair cells against tectorial membrane.


6. Info relayed to cns over the cochlear branch of cranial nerve

Midbrain

Directs unconscious motor response to sounds

Functions of the digestive system

Ingestion, mechanical processing, digestion, secretion, absorption, excretion, defense

Salivary glands

Secretion of lubricating fluid containing enzymes that break down carbs

Pharynx

Muscular propulsion of materials into the esophagus

Oral cavity



Stomach

Oral: mechanical processing.



Stomach: chemical breakdown and mechanical processing

Small intestine

Enzymatic digestion and absorption of water, organic substrates, vitamins, and ions.

Large intestine

Dehydration and compaction of undigestible materials in preparation for elimination.

Pancreas.

Exocrine cells secreted buffers and digestive enzymes. Endocrine cells secrete hormones

Gallbladder

Storage and concentration of bile

Liver

Secretion of bile for lipid digestion, storage of nutrients , other vital functions

4 layers of digestive tract

Mucosa: folds, epithelium


Submucosa: loose connective tissue and blood and lymph vessels and nerves


Muscularis externa: smooth muscle cells...contractions


Serosa: outer membrane

Mucosa

Has folds that increase surface area for absorption and permit expansion after a large meal.



Has villi in small intestine.



Has an epithelium ( moistened by glandular secretions) and loose connective tissue

Simple epithelia

Single layer of cells

Stratified epithelium

Multiple layers of cells. Specialized depending on the location and function

Squamous

Flat.



Alveoli and lining of esophagus

Columnar

Column shaped



Linings of pharynx, anus, uterus, urethra.


Cuboidal

Cube shaped cells. Epidermis and lining of the mouth

Submucosa

Loose connective tissue. Large blood vessels and lymph vessels. Nerve fibers and sensory neurons. Submucosal plexus

Submucosal plexus

Involved In controlling and coordinating contractions of smooth muscle layers and regulating secretions of digestive glands

Muscularis externa

Band of smooth muscle cells, one in a circular layer and one in a longitudinal layer. Contractions.



2 layers with myenteric plexus in between.

Parasympathetic stimulation of Muscularis externa

Increases muscle tone and activity

Sympathetic stimulation of Muscularis externa

Muscle inhibition and relaxation

Myenteric plexus

Between layers of muscular externa.



Nerves. Sensory neurons. Interneurons. Parasympathetic ganglia. Sympathetic postganglionic fibers

Serosa

Membrane that covers the Muscularis externa

Mesenteries of the serosa

Double membrane sheets. Vessels, nerves, lymph. Stabilize position of the intestines and organs.

Pacesetter cells

Trigger waves of contraction that move digestive materials

Peristalsis

Movement of material along the tract.



1. Contraction of circular muscles behind food forces it forward


2. Contraction of longitudinal muscles ahead of food.

Segmentation

Mechanical mixing of materials in small intestine

Uvula

Helps prevent food from entering the pharynx too soon.

Oral mucosa

Stratified squamous epithelium

Functions of the oral cavity (4)

1. Senses and analyses material before swallowing



2. Mechanical processing



3. Lubricates material with mucus and salivary secretions.



4. Begins digestion of carbohydrates and lipids with salivary enzymes

Lingual tonsils

Lymphoid nodules thay help resist infection

Salivary glands

3 pairs that secrete into the oral cavity.




Mostly water but also has mucins, ions, buffers, waste products, metabolites, and enzymes

Functions of salivary glands (4)

Lubricates the mouth and dissolve chemicals that stimulate the taste buds



Cleans oral surfaces



Antibodies and lysodomes help control oral bacteria



Produce salivary amylase


Salivary amylase

An enzyme that breaks down starches.



Made by parotid glands (a salivary gland)

Enamel

Contains crystalline form of calcium phosphate, the hardest biological substance.



Calcium, phosphates, and vitamin D3 are essential

What substance is the bulk of each tooth

Dentin: a mineralized mix similar to that of bone. Doesn't contain cells

Incisors

Blade shaped teeth at front. Clipping and cutting

Cuspids

Canines.


Conical with sharp tip. Tearing and slashing

Bicuspids and molara

Flattened crowns with ridges. Crushing and mashing and grinding

Esophagus

Throat. Have stratified squamous epithelium and contains mucous glands

4 steps in swallowing process

1. Oral phase: reflex response begins. Compression of bolus



2. Pharyngeal: elevation of larynx and folding of epiglottis



3. Esophageal: bolus enters esophagus. Peristalsis waves



4. Bolus enters stomach through the lower esophageal sphincter

Purpose of tonuge

Compacts debris into a bolus

Functions of the stomach (4)

Temporary storage



Mechanical breakdown



Chemical breakdown of bonds by acids and enzymes



Production of intrinsic factor for absorption of vitamin B12

Chyme

Highly acidic mixture of partially digested food

Rugae

Prominent folds and ridges in the stomach mucosa, when the stomach is empty

The stomach is lined by

Simple columnar epithelium dominated by mucus cells

What types of cells are in the gastric wall (4)

Mucus cells


Parietal cells


Chief cells


Endocrine cells



Also have gastric glands

Mucus cells

Secrete alkaline mucus that covers and protects epithelial cells from acids, enzymes, and abrasive materials

Gastric glands

Secrete gastric juice

Parietal cells in the gastric wall

Secrete intrinsic factor and hydrochloric acid

Intrinsic factor

Aids in the absorption of vitamin B12 across the intestinal lining. Needed for erythropoiesis

Erythropoiesis

Making red blood cells

Hydrochloric acid produced by Parietal cells

Lowers the pH of the gastric juices

Chief cells

Secrete a protein pepsinogen, which is converted into pepin, a proteolytic enzyme

Proteolytic

Breakdown of proteins into amino acids or smaller peptides

Endocrine cells in gastric wall

Involved in the regulation of gastric activity

3 steps of stomach movement

1. Cephalic phase: sight..smells...thought of food prepares the stomach to receive the food. Cells in gastric wall are stimulated. So is Submucosal plexus.



2. Gastric phase: food arrives in stomach. Stimulation of stretch receptors and chemoreceptors. Stimulates myenteric plexus to mix and gastrin stimulates stimulates contractions



3. Intestinal phase: chyme enters small intestine. Release of CCK and GIP resulting in reduced gastric activity in the stomach

No food is absorbed in the

Stomach

Why is no food absorbed in the stomach (4)

1. Alkaline mucus covers surface so it's not directly exposed to chyme



2. Epithelial cells lack specialized transport mechanism



3. Gastric lining is impermeable to water



4. Digestion has not completed yet.

90% of food is absorbed in the

Small intestine

3 segments of the small intestine

1. Duodenum: mixing bowl. Receives secretions from the pancreas and liver.



2. Jejunum: Most of digestion and absorption



3. Ileum: longest. Sphincter controls flow of material into large intestine

The mucosa of the small intestine is composed of

A multitude of finger like projections called villi that are covered in Simple columnar epithelium carpeted with microvilli

Each villus in the intestinal wall contains

A network of capillaries that transport respiratory gases and carries absorbed nutrients to the hepatic portal circulation for delivery to the liver. Also contains nerve endings and lymphatic capillary.

What are the 4 gastrointestinal hormones

1. Gastrin: released by stomach upon vagus nerve stimulation and arrival of food, stimulates production of acids and enzymes.



2. Secretin: released by duodenum upon chyme arrival. Targets pancreas, liver, and stomach. Inhibits gastric secretion. Stimulates bile secretion and alkaline buffers



3. CCK: made in duodenum upon arrival of chyme. Targets multiple places. Stimulates pancreatic enzymes, inhibits gastric secretions, relaxation of sphincter at bile duct



4. GIP: released by duodenum and stomach. Stimulates release of insulin by pancreatic islets. Stimulated by large amounts of fats and glucose


Gastrin

released by stomach upon vagus nerve stimulation and arrival of food, stimulates production of acids and enzymes.

Secretin

released by duodenum upon chyme arrival. Targets pancreas, liver, and stomach. Inhibits gastric secretion. Stimulates bile secretion from liver and alkaline buffers from exocrine pancreas

CCK

made in duodenum upon arrival of chyme. Targets multiple places. Stimulates pancreatic enzymes from exocrine pancreas, inhibits gastric secretions, relaxation of sphincter at bile duct

GIP

released by duodenum and stomach. Stimulates release of insulin by pancreatic islets of the endocrine pancreas. Stimulated by large amounts of fats and glucose

Pancreas

Responsible for most of digestion



Endocrine: secrete insulin and glucagon



Exocrine: produces pancreatic juice, a mixture of enzymes and buffers for the small intestine. Stimulated by hormones from the duodenum when chyme arrives: CCK.

The pancreas is primarily

Exocrine

Pancreatic amalyse

Breaks down carbs

What accounts for 70% of total pancreatic enzyme production

Proteases. = trypsin, chymotrypsin, carboxypeptidase



Break down complex proteins

What are the 3 functions of the liver

1. Metabolic regulation: regulates composition of circulating blood. All blood leaving the absorptive areas of the digestive tract flows through the liver before reaching the general circulation.



2. Hematological regulation: removal of aged and damaged red blood cells, debris and pathogens by kupffer cells



3. Bile production: help dilute and buffer acids in the chyme as it enters the small intestine

Hepatocytes. 2 functions

The predominant cell type in the liver.



body.



1. Extract absorbed nutrients or toxins from the blood before they reach the rest of the body.2. Monitor and adjust the circulating levels of organic nutrients. Ex. Synthesis and breakdown of glucagon



Can also secrete bile


What is the basic functional unit of the liver

Liver lobes that contain plates of hepatocytes.


Sinusoidal are highly permeable capillaries that flow between the plates. Hepatocytes absorb solute from the plasma and secrete proteins back.

Gallbladder

Stores and concentrates bile prior to its excretion to the small intestine.

Bile is released into the duodenum

Under stimulation of CCK

Major functon of the liver

Synthesis and secretion of bile.


Storage of glycogen and lipid reserves.


Maintenance of normal blood levels of glucose, amino acids, and fatty acids.


Inactivation of toxins.


Storage of ion reserves.


Storage of fat-soluble vitamins.


Synthesis of plasma proteins and clotting factors.


Phagocytosis of damaged red blood cells by kupffer cells.


Phagocytosis of damaged red blood cells by kupffer cells.


3 parts if the large intestine

1. Cecum: compaction


2. Colon: abundance of mucous cells and lack of villi. Pouches for distension and elongation


3. Rectum: temporary storage of feces

Functions of the large intestine

Absorbing.


Preparing fecal material for elimination.


Reabsorption of water and bile salts


Bacteria residing in colon generate 3 vitamins: K, Biotin, B5

Carbs start being broken down in the

Stomach

Lipids start being broken down in the

Small intestine. By bile salts and pancreatic lipase

Proteins start being broken down in the

Stomach by pepsin and then trypsin, etc in the small intestine

4 types of digestive enzymes

Carbohydrases: carbs and sugars


Lipases (pancreatic): triglycerides


Proteases: proteins


Nucleases (pancreatic): nucleic acids

Hypothalamus

Production of ADH and other regulatory hormones.



ADH: constructs blood vessels and makes u retain water

Endocrine cells release

Hormones into the bloodstream.


Travel to target cells: the cell must have receptors that can bind the hormone and initiate a change in cellular activity

Two types of hormones (how they affect the cell)

1. Binds to surface membrane receptors


2. Diffusion

How do hormones that bind to plasma membrane cause a reaction

1. Bind to membrane receptor coupled to a G Protein (link between first and second messenger)


2. Second messenger then activates cell activity

How does epinephrine work

1. Binds to hormone receptor.


2. Triggers G Protein


3. Activates adenylyl cyclase


4. Converts ATP to cAMP


5. Activates kinase enzymes that alter enzyme activity by phosphorylation (adding a phosphate group)

Both steroid hormone and thyroid hormone

Past directly through target cell membranes.


Steroid binds to receptors in cytoplasm or nucleus.


Thyroid binds to receptors in nucleus or mitochondria.



Thyroid hormone increases rate of ATP production

The hypothalamus provides

The highest level of endocrine control. It acts as an important link between the nervous and endocrine systems. Coordinating centers in the hypothalamus regulate the activities of the nervous and endocrine systems

What are the three mechanisms of hypothalamic control over endocrine organs

1. Production of ADH and oxytocin by hypothalamus neurons which travel through axons to pituitary gland then circulation.



2. Secretes 2 classes of regulatory hormones that control endocrine cells in the anterior lobe of the pituitary gland. RH and IH.



3. Contains autonomic nervous system centers that control the endocrine cells of the adrenal medullae in the adrenal gland..causes them to release hormones

RH = releasing hormone


IH = inhibiting hormone

RH: stimulates the synthesis and secretion of hormones by the pituitary gland.



IH: prevents the synthesis and secretion of pituitary hormones

Pituitary gland

TSH, FDH



Oxytocin and ADH



Stimulated by the hypothalamus

The hormones produces by the pituitary gland

All use secondary messengers and cAMP

Portal vessels of the pituitary gland

Blood vessels that link two capillary networks, including the vessels between the hypothalamus and the anterior lobe.



Also called portal veins because they have the structure of veins

What is the portal system of the pituitary gland

The portal system ensures that all the blood entering the portal vessels reach certain target cells before returning to the general circulation. It consists of the portal vessels that have the structure of veins

The regulatory hormones released at the hypothalamus are directly transported to the

Anterior lobe of the pituitary gland by the hypophyseal portal system

The rate of regulatory hormone secretion by the hypothalamus is regulated through

Negative feedback.



The hypothalamus releases hormones to the pituitary gland which release hormones that affect target organs. These target organs then release hormones that inhibit the pituitary gland and the hypothalamus (prevent more RH from being released)

TSH

Thyroid-stimulating hormone is released by the pituitary gland when stimulated by the hypothalamus through the TRH hormone. It targets the thyroid glands which triggers the release of thyroid hormones. As circulating concentrations of thyroid hormones rise, the rates of TRH and TSH production decline.



TRH-> TSH-> thyroid hormones

FSH

Follicle-stimulating hormone is released by the pituitary gland when the hypothalamus releases GnRH.



FSH promotes follicle and egg development in females and stimulates the secretion of estrogen. A peptide hormone called inhibin released by the ovaries inhibits the release of FSH and GnRH through negative feedback control mechanisms.

ADH

Antidiuretic hormone is released by the posterior lobe of the pituitary gland and is released when the body is low on water. It affects the kidneys and causes it to decrease the amount of water lost in urine. It also causes vasoconstriction of blood vessels that help increase blood pressure

What is the structure of the thyroid gland

The thyroid gland contains numerous thyroid follicles that are lined by an epithelium. Each follicle contains a viscous colloid, a fluid containing the thyroid hormones. A network of capillaries surrounds each follicle. Under TSH stimulation from the pituitary gland epithelial cells remove the hormones from the follicle and release them into the bloodstream

The thyroid gland contains C cells...

C cells produce Calcitonin (CT) which helps regulate calcium ion concentrations in the body fluids. C cells release calcitonin when the calcium ion concentration of the blood rises above normal. The hormone target the bones and the kidneys. The resulting reduction in blood calcium levels eliminates the stimulus and turns off the C cells

Rising blood calcium...

The thyroid gland produces calcitonin in the C cells

Falling calcium levels on the blood

The parathyroid secrets parathyroid hormone (PTH)

Parathyroid hormome

Secreted by the parathyroid to elevate blood calcium levels. Affects kidneys, bones, and digestive system

Chief cells

Parathyroid cells that produce parathyroid hormone.



Monitor the concentration of circulating calcium ions and secrete parathyroid hormone when calcium concentration falls below normal

Thyroid has ___ cells.


Parathyroid has ____ cells

Thyroid has C cells that release calcitonin to reduce blood calcium levels.



Parathyroid has chief cells that release parathyroid hormone to increase blood calcium levels

The adrenal gland

Sits on the top of each kidney.


Has 2 parts:


Adrenal cortex and adrenal medulla

The adrenal medulla produces...

Epinephrine and norepinephrine. These hormones affect most cells by increasing cardiac activity, blood pressure, glycogen breakdown, and release of lipids by adipose tissue

The pancreas is primarily an

Exocrine organ that produces pancreatic juice, a mixture of digestive enzymes and buffers for the small intestine.



The Endocrine portion called the pancreatic islets secretes insulin and glucagon

The pancreatic islets are a part of the

Endocrine pancreas and are composed of primarily alpha (glucagon) and beta (insulin) cells

What do the alpha cells and beta cells of the endocrine pancreas produce

The alpha cells produce the hormones glucagon and the beta cells produce insulin.

The purpose of glucagon and insulin is to

Regulate blood glucose concentration

When blood glucose levels rise

Beta cells secrete insulin causing the increased rate of glucose transport into target cells and glucose use. This causes blood glucose levels to decrease

When blood glucose levels fall

Alpha cells secrete glucagon which stimulates the breakdown of glycogen into glucose in the liver and skeletal muscle. Adipose tissue is also stimulated to release fatty acids for use by other tissues and proteins are broken down into their component amino acids for the liver to convert them into glucose. As a result blood glucose levels rise

Many organs have secondary endocrine functions

Examples are the intestines, the kidneys, the heart, the famous, and the gonads

What is the endocrine function of the reproductive system

In males, the interstitial cells of the testes produce the steroid hormones known as androgens, of which testosterone is the most important.



In females, estrogen is produced in the ovaries and is a steroid hormone that supports the maturation of the eggs and stimulate the growth of the lining of the uterus

In the ovaries, female sex cells develop in specialized structures called

In the ovaries, female sex cells develop in specialized structures called follicles under stimulation by FSH.



Follicle cells surrounding the ova produce estrogen

How does the negative feedback of FSH work in the female ovaries

FSH stimulates follicle maturation in the ovaries.



When FSH stimulates the follicles, the follicles also secrete inhibin, which suppresses FSH release by the anterior lobe of the pituitary gland through a negative feedback mechanism

What is adaptation syndrome

Adaptation syndrome is also known as the stress response. It has three phases: the alarm phase, the resistance face, and the exhaustion phase

What are the three phases of the adaptation syndrome

1. Alarm phase = fight or flight. The dominant hormone is epinephrine/ adrenaline.



2. Resistance phase= long term metabolic adjustments. GCs and other hormones act to shift tissue metabolism away from glucose thus increasing its availability to neural tissue.



3. Exhaustion phase = collapse of vital systems. Homeostatic regulation breaks down. Lipid reserves are exhausted. Failure of electrolyte balance

When a photon of light hits a retinal in the rhodopin molecule (visual pigment)...

The retinal changes shape (flattens) then bleaching occurs. Bleaching is when the ATP is used to restore the retinal back to its original bent shape

Vestibular complex

For balance. Otolith moves with gravity, distorting hair cells with sensory nerve endings

Organ of corti

A structure in the cochlea of the inner ear that produces nerve impulses in response to sound vibrations. Vibrations of the structure cause displacement of the cochlear fluid and movement of hair cells against tge tectorial membrane to produce electrochemical signals. The Celia are graded from long to short providing a tuning capability