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15 Cards in this Set

  • Front
  • Back
What is the typical structure of a paper?
Title, author list, affiliation.

Summary (abstract)

Introduction
Materials and Methods
Results (and figures)
Discussion

Acknowledgements
References
What should the introduction consist of?
Should give a clear idea as to why the study was set out and what it aimed to investigate:

- Should set out the background of the study

- A clear statement of the hypothesis

- The rationale of the study; how the design allows specific predictions to be tested and alternatives excluded
What should/might the methods include?
Each technique used should be described, either in detail or through a reference.

if it is the main technique of the work, it should be described in detail

other lab members should be able - based on the information - to perform the technique/repeat the experiment

describe some techniques more superficially and provide references for detail

give references only for the remaining techniques
What should the results include?
should contain all data (almost always in summarised form)

should explain and justify the analytical approach taken

should contain explanatory text, but should be confined simply to the analyses and presentation of the data

should not contain interpretation or conclusions that might be inferred from the data
What should the discussion include?
Do the results prove/disprove the hypothesis under question?

Findings should be related to those of others

main results discussed

interpretation, reasonable speculation, comments, comparisons, conclusions, future work, limitations
How to judge the quality of papers?
journal of publication

how is it regarded in reviews?

how often and over which time period is it cited?
What are the best journals? What are the next best?
Cell, Nature, Science.

Next best: neuron, nature neuroscience, journal of neuroscience
What is the impact factor of a journal?
The average number of citations of a paper in a journal. nature was top of 2009. but has been criticised as unfair, e.g. reviews are cited far more often than original research.
What is the faculty of 1000?
recommendations from over 1000 leading scientists

insider's guide to the most important papers in a particular field of interest

highlights papers on their scientific merit rather than in which journal they appear

provides an important complement to the indirect assessment provided by the impact factor
Give some other good review sources
current opinion in neurobiology - summary of progress in a particular area in the last year

nature reviews neuroscience

annual review of neuroscience

trends in neurobiology
how to tell how often it has been cited?
google scholar
How to get insight into a new topic?
pubmed search

new issues of selected journals

talk to lab members

phase 0: concentrate on top journals

phase I: screen the article - scan title for keywords, check authors names

Phase II: get the "punch line" - scan the abstract looking for key words. Read the introduction. find key references in introduction

Phase III: understanding the approach - go to the discussion, read first and last few paragraphs. scan figures and tables.

Phase IV: read paper in detail. or not.
Describe some difficulties in reading a paper
lack of background information from the reader

poorly written: some scientists are bad writers, or topic is overfamiliar making the prose impenetrable

logical connections may be left out

paper cluttered with jargon

authors do not provide clear roadmap

side issues are given as much airtime as salient ones

No explicit description of what the experiment actually was

authors can be under critical of their own work because they may: firmly believe in one model and dismiss others, don't discuss limitations, overstate findings, do not mention that other interpretations are also consistent with the data.
What stages are there in the publication of a paper?
experiments and data

manuscript

selection of journal

submission

editorial decision

Then either: rejection, acceptance, reviewing, revision, resubmission, rewriting etc..
What are the main 3 grant funding agencies in the Uk? What is the process of getting a grant?
Wellcome trust, medical research council, ERC, BBSRC

loop: preliminary data, previous publications in field
grant submission
review process
preselection (triage)
board meeting - rejection (back to beginning)/acceptance