Alzheimer And Non-Alzheimer Dementias

Front 1

In fludeoxyglucose F 18 positron emission tomography (FDG-PET), the earliest signs of changes related to Alz-heimer disease (AD) in glucose metabolism, are typically evident in the:

A) Parietal lobes
B) Temporal lobes
C) Occipital lobes
D) Frontal lobes

Back 1

Parietal Lobes

Front 2

Magnetic resonance imaging (MRI) of patients with AD typically shows atrophy in areas related to:
A) Recording of new memories
B) Motor function
C) Personality and social functioning

Back 2

Recording of new memories

Front 3

Magnetic resonance imaging (MRI) of patients with AD typically shows atrophy in areas related to:
A) Recording of new memories
B) Motor function
C) Personality and social functioning

Back 3

recording new memories

Front 4

The ratio of elevated phospho-tau to decreased beta amyloid has a high degree of sensitivity and specificity for de-tecting AD in specific brain areas.
A) True
B) False

Back 4

True

Front 5

In serial PET of patients with genetic mutations guaranteeing the onset of AD, amyloid proteins begin to build up _______ before cognitive signs appear.
A) 15 to 20 yr
B) 10 to 15 yr
C) 5 to 10 yr
D) 3 to 5 yr

Back 5

10 to 15 year

Front 6

_______ is responsible for 15% of dementia in patient populations both older than and younger than 60 yr of age.
A) Vascular dementia
B) Frontotemporal dementia
C) Lewy body dementia (LBD)
D) Alcohol-related dementia

Back 6

Vascular Dementia

Front 7

Unlike non-AD dementias, the early stages of AD do not measurably affect:
A) Personality
B) Frontal lobe function
C) Motor functions
D) Any of the above

Back 7

Any of the above. Early stages of AD affects language and memory

Front 8

Long-term studies have found that, in men >60 yr of age, _______ is associated with a >90% chance of developing a synucleinopathy.
A) Myoclonus
B) Stooped or extended posture
C) Rapid eye movement behavior disorder
D) Impaired coordination

Back 8

Rapid eye movement behavior disorder

Front 9

Which diagnostic test shows ≈80% specificity and ≈90% sensitivity in the detection of LBD?
A) FDG-PET
B) Volumetric MRI
C) Analysis of CSF
D) Amyloid PET

Back 9

FDG-PET

Front 10

Of the following modifiable risk factors, which is the most significant for preventing or delaying the onset of AD?
A) Physical exercise
B) Cognitive exercise
C) Smoking
D) Alcohol consumption

Back 10

Exercise