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3 Cards in this Set
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How do you diagnosis perioperative allergic reaction?
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- Identify Grading scale of severity of reaction - Dx evidence of: 1) elevated blood histamine levls (increased 30 mins to 2 hours after rxn) 2) Serum tryptase lvl are elevated, blood drawn 15-60mins for Grade I & II rxn and within 30 mins to 2 hours for Grade III & IV rxn 3) IgE assays 4) Leukocyte histamine release test --> useful for rxn to NMB agents 5) **Skin testing is gold standard for dx
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What is the four-step grading scale for severity of allergic reaction?
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- Grade I : cutaneous-mucous signs (erythema, urticaria, angioedema)
- Grade II: Mild cutaneous-mucous features that may be associated with cardiovascular (tachycardia, bradycardia, arrhythmias, & hypotension) and/or respiratory signs - Grade III: Cardiovascular collapse that may or may not be associated with cutaneous-mucous sign and/or bronchospasm - Grade IV: Full-blown cardiac arrest |
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What is an anaphylactoid reaction?
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= Chemotoxic processes, where the triggering agent results in direct activation of complement and histamine release and degranulation of mast cells and basophils.
- Clinically indistinguishable from anaphylactic rxn, but WITHOUT and immunologic basis (non-IgE) |
