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26 Cards in this Set
- Front
- Back
alpha-1 receptor
|
Gq/11, IP3
Constricts blood vessels |
|
alpha-2 receptor
|
Gi, lowers cAMP
constricts blood vessels presynaptic transmitter release |
|
beta-1 receptor
|
Gs, increases cAMP
increases heart rate and force |
|
beta-2 receptor
|
Gs, increases cAMP
relaxes gut, blood vessels and bronchioles |
|
alpha-methyltyrosine
|
Inhibits Tyrosine hydroxylase
|
|
Carbidopa
|
Inhibits DOPA decarboxylase
|
|
Disulfiram
|
Inhibits D-beta hydroxylase
|
|
Iproniazid
Tranylcypromine |
Non Specific MAO inhibitors
|
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Clorgyline
|
MAO-A inhibitor
|
|
Selegiline
|
MAO-B inhibitor
|
|
Entacapone
|
COMT inhibitor
Parkinson's |
|
Uptake 1
|
Neuronal, high affinity.
Inibited by imipamine, cocaine |
|
Uptake 2
|
Non neuronal, low affinity
Inhibited by corticosteriods |
|
Adrenaline
|
α>β
|
|
Noradrenaline
|
α>β1>β2
|
|
Phenylephidrine
|
α1 agonist
|
|
Clonidine
|
α2 agonist
Hypertension, lowers presynaptic transmitter release |
|
Methylnoradrenaline
|
False transmitter, α2 agonist. Lowers vasoconstriction
|
|
Labetalol
|
Mixed α1 and β antagonist
|
|
Dobutamine
|
β1 agonist, positive ionotropic effect
|
|
Salbutamol
|
β2 agonist, bronchodilate
|
|
Prazosin
|
α1 antagonist
Vasodilatation |
|
Yohimbine
|
α2 antagonist
Reverse actions of clonidine |
|
Propranolol
|
Mixed β antagonist
|
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Atenolol
|
β1 antagonist, heart failure and dysrhythmmias
|
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Butoxamine
|
β2 antagonist
|