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36 Cards in this Set

  • Front
  • Back
Adrenergic drugs stimulate the ____ system.
Sympathetic
Catecholamines _____ cross the BBB.
cannot
What enzymes break down catecholamines?
MAO and COMP
Noncatecholamines _____ cross the BBB and have _____ half-lives than catecholamines.
can, longer
What would activation of alpha 1 receptors do?
Vasconstriction of skin and membranes and dilation of the eye
What would activation of alpha 2 receptors do?
Inhibit release of norepinephrine
What would activation of beta 1 receptors do?
Activation of the heart
What would activation of beta 2 receptors do?
Relaxing of lung and uterus tissue
What would activation of dopamine do?
Dilation of kidneys
What receptors does Isoproterenol activate? What is its use?
Beta 1 and 2
Asthma
What receptors does dopamine activate? What is its use?
Dopamine and Beta 1
Shock
What receptors does epinephrine activate?
Alpha 1 and 2
Beta 1 and 2
What receptors does norepinephrine activate?
Alpha 1 and 2
Beta 1
What is the effect of alpha blockage?
Relief of Hypertension
Benign Prostatic Hyperplasia
Pheochromocytoma
What are the adverse effects of alpha blockage?
Hypotension
Reflex Tachycardia
Inhibition of Ejaculation
Prazosin is a _________.
Alpha 1 Blocker
What is the prototype Alpha 1 Blocker?
Prazosin
What is the therapeutic use of Beta Blockers?
Relief of Hypertension
Angina
Myocardial Infarction
Heart Failure
Glaucoma
What are the adverse effects of Beta Blockers?
Beta 1- Bradycardia, AV Heart Block, and Precipitation of Heart Failure
Beta 2- Bronchial constriction
Propranolol is a _______.
Beta Blocker
What is the prototype beta blocker drug?
Propranolol
What is a prototype beta 1 blocker (cardioselective) drug?
Metoprolol
Metoprolol is a ________.
Beta 1 cardioselective blocker
What do adrenergic neuron-blocking agents do?
Act within terminals to decrease NE release
What do centrally acting Alpha 2 agonists do?
Act as an adrenergic antagonist
What is the prototype adrenergic neuron-blocking agent?
Reserpine
Reserpine is a _______.
Adrenergic neuron blocking agent
How does reserpine work?
Exposes the terminal to MOA
Clonidine is a ______.
Centrally acting Alpha 2 agonist
What is the prototype centrally acting alpha 2 agonist?
Clonidine
What is Methyldopa?
Centrally Acting Alpha 2 Agonist
What is the prototype for a centrally acting Alpha 2 agonist?
Methyldopa
Methyldopa is active when taken into the brainstem.
T or F
False
What is the theraputic use of centrally acting alpha 2 agonists?
Relief of hypertension
Drugs of the CNS often show changes right away.
T or False
False
Most drugs of the CNS were discovered accidentally.
T or False
True