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36 Cards in this Set
- Front
- Back
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A1 adrenergic receptor
order of catecholamine potency |
Ne >= Epi >> Iso
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A2 adrenergic receptor
order of catecholamine potency |
Epi >= NE >> Iso
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A1 adrenergic receptor agonist
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phenylephrine
methoxamine |
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phenylephrine
methoxamine |
A1 adrenergic receptor agonist
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A2 adrenergic receptor agonist
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clonidine
brimonidine |
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clonidine
brimonidine |
A2 adrenergic receptor agonist
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A1 adrenergic receptor antagonist
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prazosin
terazosin |
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prazosin
terazosin |
A1 adrenergic receptor antagonist
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A2 adrenergic receptor antagonist
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yohimbine
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yohimbine
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A1 adrenergic receptor antagonist
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A1 receptor location
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- SMOOTH MUSCLE
- salivary and sweat glands - liver |
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A1 receptor responses
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- SMOOTH MUSCLE - contraction
- salivary and sweat glands - K+ release/secretion - liver - K+ release |
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A2 receptor location
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- vascular smooth muscle
- Pancreatic B-cells - platelets - presynaptic terminal |
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A2 receptor responses
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- vascular smooth muscle - contraction
- Pancreatic B-cells - decreased insulin secretion - platelets - aggregation - presynaptic terminal - decreases adrenergic release (feedback inhibition) |
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B1 adrenergic receptor
order of catecholamine potency |
Iso > Epi = NE
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B2 adrenergic receptor
order of catecholamine potency |
Iso > Epi >> NE
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B1 adrenergic receptor
agonist |
dobutamine
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dobutamine
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B1 adrenergic receptor
agonist |
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B2 adrenergic receptor
agonist |
albuterol
ritodrine salmeterol |
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albuterol
ritodrine salmeterol |
B2 adrenergic receptor
agonist |
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B1 adrenergic receptor
antagonist |
metoprolol
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metoprolol
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B1 adrenergic receptor
antagonist |
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B1 and B2 adrenergic receptor
antagonist |
propranolol
timolol |
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propranolol
timolol |
B1 and B2 adrenergic receptor
antagonist |
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B3 adrenergic receptor
order of catecholamine potency |
Iso = NE > Epi
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B1 adrenergic receptor locations
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- HEART
- J-G cells |
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B1 adrenergic receptor responses
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- HEART - increased rate, force, conduction and velocity
- J-G cells - increased renin release |
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B2 adrenergic receptor locations
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- Smooth muscle (vascular, GU, resp)
- skeletal muscle - liver - mast cells |
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B2 adrenergic receptor responses
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- Smooth muscle (vascular, GU, resp) -- relaxation/vasodilation
- skeletal muscle - tremor, glycogenolysis - liver - gluconeogenesis - mast cells - decreases mast cell release |
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B3 adrenergic receptor location/responses
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- located in adipose tissue -- lipolysis
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NE active at which receptors?
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A1, A2, B2
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Epi active at which receptors?
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A1, A2, B1, B2
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Iso active at which receptors?
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B1, B2
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DA active at which receptors?
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D1, B1
dopaminergic neurons of the kidey --> vasodilation of the renal beds |
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Do (doputamine) active at which receptors?
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B1
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Affect of Epi on the SA node?
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Increases Ica (slow inward) --> increases outward Ik --> increases pacemaker If
increased rate or rise, amplitude decreased delay between beats (faster repolarizaion) --> increase HR |
