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36 Cards in this Set
- Front
- Back
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Adrenergic drugs stimulate the ____ system.
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Sympathetic
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Catecholamines _____ cross the BBB.
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cannot
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What enzymes break down catecholamines?
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MAO and COMP
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Noncatecholamines _____ cross the BBB and have _____ half-lives than catecholamines.
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can, longer
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What would activation of alpha 1 receptors do?
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Vasconstriction of skin and membranes and dilation of the eye
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What would activation of alpha 2 receptors do?
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Inhibit release of norepinephrine
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What would activation of beta 1 receptors do?
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Activation of the heart
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What would activation of beta 2 receptors do?
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Relaxing of lung and uterus tissue
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What would activation of dopamine do?
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Dilation of kidneys
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What receptors does Isoproterenol activate? What is its use?
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Beta 1 and 2
Asthma |
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What receptors does dopamine activate? What is its use?
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Dopamine and Beta 1
Shock |
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What receptors does epinephrine activate?
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Alpha 1 and 2
Beta 1 and 2 |
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What receptors does norepinephrine activate?
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Alpha 1 and 2
Beta 1 |
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What is the effect of alpha blockage?
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Relief of Hypertension
Benign Prostatic Hyperplasia Pheochromocytoma |
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What are the adverse effects of alpha blockage?
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Hypotension
Reflex Tachycardia Inhibition of Ejaculation |
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Prazosin is a _________.
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Alpha 1 Blocker
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What is the prototype Alpha 1 Blocker?
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Prazosin
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What is the therapeutic use of Beta Blockers?
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Relief of Hypertension
Angina Myocardial Infarction Heart Failure Glaucoma |
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What are the adverse effects of Beta Blockers?
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Beta 1- Bradycardia, AV Heart Block, and Precipitation of Heart Failure
Beta 2- Bronchial constriction |
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Propranolol is a _______.
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Beta Blocker
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What is the prototype beta blocker drug?
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Propranolol
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What is a prototype beta 1 blocker (cardioselective) drug?
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Metoprolol
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Metoprolol is a ________.
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Beta 1 cardioselective blocker
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What do adrenergic neuron-blocking agents do?
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Act within terminals to decrease NE release
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What do centrally acting Alpha 2 agonists do?
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Act as an adrenergic antagonist
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What is the prototype adrenergic neuron-blocking agent?
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Reserpine
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Reserpine is a _______.
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Adrenergic neuron blocking agent
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How does reserpine work?
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Exposes the terminal to MOA
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Clonidine is a ______.
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Centrally acting Alpha 2 agonist
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What is the prototype centrally acting alpha 2 agonist?
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Clonidine
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What is Methyldopa?
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Centrally Acting Alpha 2 Agonist
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What is the prototype for a centrally acting Alpha 2 agonist?
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Methyldopa
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Methyldopa is active when taken into the brainstem.
T or F |
False
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What is the theraputic use of centrally acting alpha 2 agonists?
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Relief of hypertension
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Drugs of the CNS often show changes right away.
T or False |
False
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Most drugs of the CNS were discovered accidentally.
T or False |
True
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