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16 Cards in this Set
- Front
- Back
- 3rd side (hint)
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Isoprenalime |
Activates beta adtenergic receptor at the heart (B1), lungs (B2), skeletal muscles (B2) and GI tract; Non selective Increases isotropic and chronotropic effects on heart Relaxes BV, skeletal muscles, GI tract, bronchi muscles Used to treat cardiac arrest, heart block and acute asthma attack Adverse effects: tachycardia, hypotension, headache, flushing, mild tremors |
Selectivity, receptors, location of actions, indications, adverse effects |
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Dobutamine |
Activates beta 1 adrenergic receptor at the heart. Works to increase isotropic and chronotropic effects Used to treat cardiac arrest, cardiac failure, heart block Hypertension (-dobutamine) or hypotension (+dobutamine) as dobutamine exists as a racemic mixture and can act as an alpha 1 agonist (-) or antagonist (+) |
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Salbutamol |
Activates beta 2 adrenergic receptors to relax bronchi muscle, uterus and blood vessels. Relaxes bronchi muscles to promote bronchodilaton and airflow. Can be used to delay labour by reducing uterine contractions Also decreases decreases duration of skeletal muscle contractions Adverse effects: Tremors, Headche, flushing, tachycardia ( off target activation at higher doses) Hypokalemia (decrease in K+), lactic acidosis |
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Phenylephrine |
Alpha 1 adrenergic receptor agonist. Redistribution of blood flow due to vasoconstriction, thus reducing oedema at nasal mucosa Side effects: CNS stimulation, tachycardia, hypertension, arrythmia |
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Propanolol |
Blocks beta adrenergic receptors (non selective) at heart to decrease isotropy and chronotropy and blocks beta receptor at bladder to decrease renin production causing decrease CO. Leads to increased oxygenation of myocardium Decrease insulin levels Decrease serum free fatty acids Decrease aqueous humour production, leading to decreased oracular preasue Adverse effects: cardiac failure, bradycardia (beta 1) Bromchospasm, cold extremities (beta 2) |
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Metopropolol |
Blocks beta 1 adrenergic receptor at heart and bladder Decreaaes chronotropy and inotropy (decrease CO) and reduces renin production (decrease blood volume and hence CO), improving oxygenation of myocardium. Also decreases BP Adverse effects: Common-bradycardia, hypotension Rare- Heart block |
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Prazosin |
Blocks alpha 1 receptor in prostate smooth muscles. Relaxes prostate smooth muscle and urinary sphincter, decreasing occlusion of prostate on urethra Adverse effects: Common: Postural hypotensiin, Nasal congestion, Blurred vision Rare: Priapism (painful penile erection lasting hours due to relaxation of smooth muscle) |
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Tamsulosin |
Blocks alpha 1 adrenergic receptor in smooth muscles Inhibits smooth muscle contractions in prostate, improve urodynamics Adverse effects: Hypotension, Dizziness, abnormal ejaculation, floppy iris syndrome after cataract surgery |
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Indirectly acting sympathomemetric |
Amphetamin Ephedrine Tyrmine |
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Action of indirectly sympathimemtric |
Mimic sympathetic nervous sytem. Does not bind directly to agonist but promotes release of more noradrenaline from nerve terminal |
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Uptake 1/Noradrenalinetransporter inhibitor |
Block uptake of noradrenaline into nerve terminal, increase duration of action of released noradrenaline Cocaine Amphetamine AmphetamineDespramine AmphetamineDespramine Despramine |
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MAO Inhibitor |
Moclobemide Decrease metabolism of noradrenaline by inhibiting MAO. Increase CNS synaptic concentrations of serotonin, noradrenaline, dopamine. Used for depression Adverse effects: Common: CNS overstimulation (insomia, restlessness, anxiety), nausea Rare: Hypertension, Peripheral edema |
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Alpha 1 antagonists |
Prazosin Tamsulosin Used to treat beningn prostate hyperplasia |
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Beta adrenergic receptor antagonist |
Propanolol (non selective) Metroprolol (B2) |
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Alpha receptor agonist |
Phenylephedrine |
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Beta agonist |
Isoprenaline non selective Dobutamine (B1 selective) heart failure, arrest, block Salbutamol (B2 selective) asthma, labour Mirabegron (B3 selective) OAB Think of asthma, diabetes |
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