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23 Cards in this Set
- Front
- Back
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alpha-1 receptor actions
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- vasoconstriction
- increased peripheral resistance - increased blood pressure - mydriasis (dilation) - increased closure of internal sphincter of bladder - activation of receptor leads to increase of intracellular calcium |
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alpha-2 receptor actions
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- inhibition of NE release
- inhibition of insulin release |
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beta-1 receptor actions
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- tachycardia
- increased lipolysis - increased myocardial contractility - increased release of renin |
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beta-2 receptor actions
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- vasodilation
- slightly decreased peripheral resistance - bronchodilation - increased muscle & liver glycogenolysis - increased release of glucagon - relaxed uterine smooth muscle |
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epinephrine
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- alpha1, alpha2, beta1, beta2 agonist
- a catecholamine - synthesized from tyrosine in adrenal medulla - low dose = beta response - high dose = alpha response - drug of choice for anaphylactic shock |
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norepinephrine
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- alpha1, alpha2, beta1 agonist
- a catecholamine - vasoconstriction & increased peripheral resistance --> increased BP - get reflex bradycardia - tx shock (not anaphylactic) |
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isoproterenol
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- beta1, beta2 agonist
- a catecholamine - increases HR - bronchodilation - tx cardiac arrest, asthma |
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dopamine
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- beta1, dopaminergic (alpha1 @ high doses) agonist
- a catecholamine - dilates renal & splanchnic arterioles - miracle drug for kidney failure - tx shock, CHF |
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dobutamine
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- beta1 agonist
- a catecholamine - increases CO in congestive HF |
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phenylephrine
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- alpha1 agonist
- vasoconstriction - dilates pupil; no effect on accommodation - CI: HTN, MAOIs, pts on reserpine, guanethidine, pulmonary edema, arrhythmia |
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dapiprazole (Rev-eyes)
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- an alpha1 ANTAGONIST
- inhibits dilator (radial fibers) - competes w/NE - displaces phenylephrine; no effect on tropicamide - makes eyes red |
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amphetamine
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- indirect-acting adrenergic agonist
- causes release of catecholamine stores - increases BP - use for Horner's dx |
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tyramine
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- indirect-acting adrenergic agonist
- normal byproduct of tyrosine metabolism - no therapeutic use |
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hydroxyamphetamine (Paredrine)
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- indirect-acting adrenergic antagonist
- test for postganglionic Horner's; also used to tx |
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cocaine
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- blocks NE reuptake, increasing its time @ the receptor
- Horner's Dx |
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ephedrine
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- stimulates alpha and beta receptors and CNS
- releases NE from the terminal - diet pills, nasal decongestant - tx asthma, nasal decongestant, improves motor function in MG - increases BP |
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apraclonidine (Iopidine)
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- alpha1, alpha2 agonist
- decreases IOP via aqueous suppression - use in acute angle closure - tachyphylaxis w/time - mydriasis, conjunctival blanching |
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metaraminol
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- mixed-action adrendergic agonist
- tx shock & acute hypotension |
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methoxamine
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- alpha1 agonist
- vasoconstriction, increased BP - tx supraventricular tachycardia |
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clonidine
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- alpha2 agonist
- decreases sympathetic activity - tx HTN - acts on CNS |
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metaproterenol
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- beta2 > beta1 agonist
- tx asthma, reverse bronchospasm |
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terbutaline
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- beta2 agonist
- tx bronchospasm and premature labor - longer duration than metaproterenol |
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albuterol
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- beta2 agonist
- tx bronchospasm & premature labor - most widely used as an inhaler |
