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12 Cards in this Set
- Front
- Back
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places that use Ach as a NT
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preganglionic fibers to adrenal medulla; autonomic ganglia; post-ganglionic fibers of parasympathetic
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general actions of cholinergic agonists
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decreases: HR, CO
increases: salivation & sweating, accommodation, GI motility, bronchial secretions miosis bladder stimulation |
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bethanechol
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- selectively muscarinic cholinergic agonist
- stimulates atonic bladder |
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carbachol
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- muscarinic & nicotinic cholinergic agonist
- miotic agent to tx glaucoma |
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pilocarpine
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- selectively muscarinic cholinergic agonist
- rapid miosis & contraction of ciliary muscle - CI in high myopes - topical tx for glaucoma (both narrow & open angle) - SEs: enters CNS; sweating, lacrimation, salivation; nausea, vomiting, diarrhea |
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physostigmine
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- reversible acetylcholinesterase inhibitor (cholinergic agonist)
- miosis, spasm of accommodation - tx glaucoma - use in atropine overdose - SEs: convulsions, bradycardia, paralysis of skeletal muscle |
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neostigmine
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- reversible Achesterase inhibitor (indirect cholinergic agonist)
- symptomatic tx of MG - curarine antidote |
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pyridostigmine
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- reversible Achesterase inhibitor (indirect cholinergic agonist)
- chronic management of MG |
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edrophonium
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- reversible Achesterase inhibitor (indirect cholinergic agonist)
- tensilon test for MG |
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isofluorophate
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- irreversible anticholinesterase (indirect cholinergic agonist)
- intense miosis - tx POAG - accommodative esotropia - SEs: myokymia, bronchiolar constriction, parkinsonism - systemic poisoning - tx overdose w/atropine, pralidoxime |
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echothiophate
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- irreversible anticholinesterase (indirect cholinergic agonist)
- tx POAG, accommodative esotropia - use to break synechiae - SE include iris cysts |
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pralidoxime
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- reactivates Achesterase
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