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77 Cards in this Set
- Front
- Back
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Third Line of Defense
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not present as birth; takes about 2mos to activate
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Natural
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something thats gonna happen in nature
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Natural-Active
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when one comes in contact with a pathogen and one develops protective immunity
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Natural-Active
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when chile gets chx pox ONLY ONCE bc body is then immuned
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Natural-Passive
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mother to child; antibodies through breast milk
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Natural-Passive
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will eventually disappear and baby has to develop its own
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Artificial
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stimulated by man
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Artificial-Active
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given a vaccine to develop protective immunity
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Artificial-Passive
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give a patent antibodies developed by another individual
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Innate, nonspecific
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First and Second line of Defense
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Acquired, specific
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third line of defense
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3rd Line of Defense
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B and T lymphocytes, antibodies, cytotoxicity
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Second Line of Defense
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comes immediately into play if infectious agents make it past the surface defenses
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Second Line of Defense
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phagocytes that destroy foreign matter and inflammation which holds infections in check
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Complement
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acts in a cascade fashion
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Neutrophils
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function primarily as phagocytes
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Monocytes
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develop into macrophages
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Dolor
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specifies pain in inflammation
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memory cells
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recalls a previous immune response
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4 processes in 2nd line of defense
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inflammation, injury, vascular reactions then edema and pus formation
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Phagocytosis
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occurs with inflammation if a microorganism is present
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C3 is called to the area
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after phagocytosis occurs
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complement binds to the cell
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after phagocytosis and C3 is called to the area
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PAMP
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each cell has many of these receptors
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MHC I Receptors
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inherited from parents
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MHC I
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the receptor tested for when trying to find a donor
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MHC II
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found on antigen presenting cells (macrophages, dendritics, Bcell lymphocytes)
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MHC II
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not on Tcell or other guys
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Bcell receptor
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combine 2 antigens
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Bcells
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lymphocytes found in bone marrow
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Tcell receptor
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found only on Tcell one spot for binding antigens
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Tcell receptor
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lymphocyte formed in bone marrow
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Antigen
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comes from the infectious cell
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PAMP and MHCII receptors
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identify as "MY" cell
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Neutrophil, Eosinophil, and Monocyte
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no role in 3rd line
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Neutrophil, Eosinophil, and Monocyte
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strictly phagocytic cells in 2nd line found in the blood
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Macrophage and Dendritic cells
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float around blood do phagocytosis; can present antigen
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Macrophage and Dendritic cells
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involved in initiation of 3rd line of defense
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Antigen presenting receptor
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required in the 3rd line of defense
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Bcells
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in lymph nodes
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Receptors
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all proteins genetically controlled; complex make-up
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Bcells
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goes to bone for maturation to get receptors; antigen specific receptors
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Tcell
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go to thymus for maturation and receive receptors
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T-helper cell
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Tcell receptor and CD4 receptor
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Bcell response
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humoral immunity
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Bcell response
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doesn't have PAMP receptor
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Bcell response
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presents out on MHCII
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once Bcell is activated
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produce memory cells and plasma cells
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plasma cells
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produce IgM and IgG
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IgM and IgG
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short lived and produced by plasma cells
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Humoral Immunity
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Bcell response
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Bcell divides into two cells
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involved in 2nd and 3rd line of defense
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Bcell grows, matures, and divides into these two
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memory cells and plasma cells
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Memory cells
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type of cell that lives a various amount of time
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plasma cell
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type of cell that lives a few days and produces antibodies quickly
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Opsonization
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antibodies coat bacteria; aka...straight jacket
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Neutralization
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antibodies fill the surface receptors on a virus or the active site on a bacterial protein preventing them from attaching
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Agglutination
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cross-link bacteria
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Precipitation
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aggregate antigen molecules
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Complement
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lysing bacterial cells; lose insides
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Primary Response
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first exposure 10-12 days
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IgM and IgG
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antibodies that can pass thru placenta to baby
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Anamnestic response
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2ndary response; immediate production of antibodies
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IgM
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produced by Bcells
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IgG
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produced by Bcells and can cross placenta
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memory cells
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second response; rapid and intense; acquired immunity to the antigen
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Superantigen
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over stimulates an immune response
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Tcell Response
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activation of Bcells, stimulate macrophages to clean up, and forms memory cells
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Cytotoxic Tcell
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Tcell receptor, CD8 receptor, and MHC I receptor
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Cytotoxic Tcell
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work on viruses, cancer cells, human cells (other than own), and non-human cells
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Cytotoxic Tcell
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participants in graft rejections
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Cytotoxic Tcell
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presents antigen on MHCI receptor
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Cytotoxic Tcell
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once activated becomes "KILLER CELL"
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Cytotoxic Tcell
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directly targets cells, puts holes in membrane and destroys DNA
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Cytotoxic Tcell
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destroys cancer cells
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Cytotoxic Tcell
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immunosuppressants given to cancer patients to slow this receptor down
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Cytotoxic Tcell
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wiped out by immunosuppressants
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