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34 Cards in this Set
- Front
- Back
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The first host response to a nonspecific tissue injury |
Inflammation |
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What are the components of innate immunity |
Skin as a barrier, inflammation bring leukocytes to dammage tissue, fever is a pyrogen response to rid body of bacteria |
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Which of the following is an important phagocytic cell found in the human body |
Neutrophil |
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All blood cells originate from the |
Hematopoietic stem cells |
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The cells that primarily involved in all immune responses are |
Leukocytes |
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Antibodies are made from |
B cells that are plasma cels |
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CD4 cells are |
T helper cells |
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CD8 cells are often |
T cytotoxic cells |
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Antigens interact with antibodies at |
The outer end of each arm of the Y |
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Macrophages and dendritic cells are |
Antigen presenting cells |
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Self vs nonself |
Originated as made in the body vs foreign object or viewed as foreign object. |
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Antimicrobial substances found on the surface of the skin and in mucous |
Lysozyme Lactofarin Defensins |
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An enzyme that degrades peptidoglycan that is found in tears and saliva |
Lysozyme |
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Sequestors iron found in saliva, mucous, and breast milk |
Lactoferrin |
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Antimicrobial peptides found in mucous make holes in microbial membranes |
Defensins |
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Protein receptors on the surface of macrophages that recognize general patterns of LPS and peptidoglycan |
Pattern recognition cells that are Toll like receptors |
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TLR's can |
Tigger phagacytosis, chemokines release other immune cells, proinflamatory cytokines |
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What activated compliment bound to pathogen is a signal for phagacytosis |
C3b |
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What complements induce a inflammatory response |
C3b and C5a |
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What compliments combines to cause lysis of foreign cells? |
C5b- C9 |
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What complement binds to microbial functioning as an opsonin? |
C3b |
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What compliment destroys pathogens directly by making holes in the pathogens memebrane |
C9 MAC membrane attack complex |
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Proinflamatory cytokines |
C3a |
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What does vasodilation cause? |
Increase blood flow and heat |
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What causes capillary permeability induces edema and pain |
Diapedesis |
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What action of antibodies that directly kill bacteria |
Anti-body dependant cellular cytosis bind to cell than become a target for natural killer cells |
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_________ bind exogenous antigen have CD4 marker on cell surface are |
MHC II |
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Exogenous antigen is |
Extracellular antigen |
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______binds endogenous antigen, intercellular. Found int he cytoplasma of the cell. Virus or cancer hid |
mHC I |
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MHC I display non self peptide |
sends a signal to destroy cell by T cytotoxic cells |
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First antibody to respond to infection, very good at cross's linking |
IgM |
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Antibody found in secretion; breast milk, mucous, tears, saliva |
IgA |
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B cell receptors |
IgD |
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Epitope is an |
Antigen determinant helps with antigen recognition |
