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60 Cards in this Set
- Front
- Back
clinical signs of nephrotic syndrome
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proteinuria
edema hyperlipidemia hypercoagulability |
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loss of antithrombin III occurs in nephrotic/nephritic syndrome
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nephrotic syndrome
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clinical signs of nephritic syndrome
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hematuria
oliguria HTN |
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micro findings in nephritic syndrome
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crescentic lesions
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plugging up of Bowmans space occurs in nephritic/nephrotic syndrome
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nephritic syndrome
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thinning of the GBM occurs in nephritic/nephrotic syndrome
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nephritic syndrome
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urinalysis of nephritic syndrome
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hematuria
RBC casts protein <3.5 g/day |
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test used to rule out post renal ARF
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bladder scan
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test to rule out prerenal ARF
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specific gravity
urine osmolality FeNa |
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cholesterol is elevated in nephrotic/nephritic syndrome
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nephrotic syndrome
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decreased calcium is seen in nephrotic/nephritic syndrome
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nephrotic syndrome
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tx of nephrotic syndrome usually always includes in addition to others
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statins
ACE-I fluid and salt restriction |
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sudden onset
most common nephrotic syndrome in children |
minimal change disease
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cause of minimal change disease
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idiopathic
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nephrotic disease associated with medications
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minimal change disease
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nephrotic disease associated lymphomas
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minimal change disease
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tx of minimal change disease
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high dose steroids for 8 weeks
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kidney biopsy findings in minimal change disease
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effacement of podocytes
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number one cause of nephrotic syndrome in african americans
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focal segmental glomerulosclerosis
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nephrotic disease associated with HIV
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focal segmental glomerulosclerosis
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mechanism of damage in focal segmental glomerulosclerosis
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HTN causes hyperfiltration, which causes increased ECM and tamponade of glomerulus
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cells that are damaged in focal segmental glomerulosclerosis
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epithelial
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nephrotic disease associated with massive obesity and obstructive sleep apnea
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focal segmental glomerulosclerosis
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nephrotic disease associated with IV heroin use
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focal segmental glomerulosclerosis
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clinical signs of focal segmental glomerulosclerosis
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asymptomatic at first with microscopic hematuria
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prognosis of focal segmental glomerulosclerosis
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50% progress to end stage renal disease
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nephrotic disease where antibody/antigen complexes are deposited in the mesangial matrix
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membranous glomerulonephropathy
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nephrotic disease associated with malignancies
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membranous glomerulonephropathy
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nephrotic disease associated with hep B/C and syphilis
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membranous GN
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workup of membranous GN
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hepatitis
cancer screens |
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tx of membranous GN
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steroids
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nephrotic disease seen in diabetics
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diabetic glomerulosclerosis
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lesions found on biopsy of diabetic glomerulosclerosis
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Kimmelstiel-Wilson nodules
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nephritic syndrome that occurs 2-3 days post infection
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IgA nephropathy
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nephrotic syndrome associated with Henoch-Schonlein purpura
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IgA nephropathy
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3 different presentations seen in IgA nephropathy
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macroscopic hematuria
microscopic hematuria high blood pressure |
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nephritic syndrome with normal C3 and C4 levels
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IgA nephropathy
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what is Henoch-Schonlein purpura
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disease of children with IgA deposits in skin, GI, kidney and joints
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clinical signs of Henoch-Schonlein purpura
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lower extremity bruising
bloody diarrhea hematuria and HTN arthralgia |
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tx of Henoch-Schonlein purpura
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supportive
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nephritic disease that presents 2 - 3 weeks post infection
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post-infectious GN
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antigen is deposited where in post-infectious GN
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subendothelium
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C3 and C4 levels in post-infectious GN
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low
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test for post-infectious GN
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ASO titer
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treatment of post-infectious GN
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none
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nephritic syndrome that is usually caused by a secondary condition like sjogrens or SLE
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membranoproliferative GN
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nephritic syndrome with low C3 and normal C4
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membranoproliferative GN
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nephritic syndrome that is ANCA positive (Ig to type IV collagen)
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anti-GBM/goodpastures
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prognosis for anti-GBM/goodpastures
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death if not treated
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rapid onset of HTN
oliguria |
anti-GBM/goodpastures
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in goodpastures syndrome there is damage to both the kidney and the
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lung (hemoptysis)
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treatment for anti-GBM/goodpastures syndrome
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steroids
plasmapheresis if pulmonary hemorrhage* |
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two types of small vessel vasculitis
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Wegener's granulomatosis
microscopic polyangitis |
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decreased appetite
weight loss hematruia polymyalgia |
small vessel vasculitis
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antibodies present in Wegeners granulomatosis
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c-ANCA
anti-PR3 |
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antibodies present in microscopic polyangitis
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c-ANCA
anti-MPO |
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acute onset of hematuria
proteinuria edema pancytopenia |
lupus nephritis
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antibodies present in lupus nephritis
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anti-Sm
anti-DS DNA |
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classes of lupus nephritis that are treated
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class III and above
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treatment of lupus nephritis
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steroids (class III and above)
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