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60 Cards in this Set

  • Front
  • Back
clinical signs of nephrotic syndrome
proteinuria
edema
hyperlipidemia
hypercoagulability
loss of antithrombin III occurs in nephrotic/nephritic syndrome
nephrotic syndrome
clinical signs of nephritic syndrome
hematuria
oliguria
HTN
micro findings in nephritic syndrome
crescentic lesions
plugging up of Bowmans space occurs in nephritic/nephrotic syndrome
nephritic syndrome
thinning of the GBM occurs in nephritic/nephrotic syndrome
nephritic syndrome
urinalysis of nephritic syndrome
hematuria
RBC casts
protein <3.5 g/day
test used to rule out post renal ARF
bladder scan
test to rule out prerenal ARF
specific gravity
urine osmolality
FeNa
cholesterol is elevated in nephrotic/nephritic syndrome
nephrotic syndrome
decreased calcium is seen in nephrotic/nephritic syndrome
nephrotic syndrome
tx of nephrotic syndrome usually always includes in addition to others
statins
ACE-I
fluid and salt restriction
sudden onset
most common nephrotic syndrome in children
minimal change disease
cause of minimal change disease
idiopathic
nephrotic disease associated with medications
minimal change disease
nephrotic disease associated lymphomas
minimal change disease
tx of minimal change disease
high dose steroids for 8 weeks
kidney biopsy findings in minimal change disease
effacement of podocytes
number one cause of nephrotic syndrome in african americans
focal segmental glomerulosclerosis
nephrotic disease associated with HIV
focal segmental glomerulosclerosis
mechanism of damage in focal segmental glomerulosclerosis
HTN causes hyperfiltration, which causes increased ECM and tamponade of glomerulus
cells that are damaged in focal segmental glomerulosclerosis
epithelial
nephrotic disease associated with massive obesity and obstructive sleep apnea
focal segmental glomerulosclerosis
nephrotic disease associated with IV heroin use
focal segmental glomerulosclerosis
clinical signs of focal segmental glomerulosclerosis
asymptomatic at first with microscopic hematuria
prognosis of focal segmental glomerulosclerosis
50% progress to end stage renal disease
nephrotic disease where antibody/antigen complexes are deposited in the mesangial matrix
membranous glomerulonephropathy
nephrotic disease associated with malignancies
membranous glomerulonephropathy
nephrotic disease associated with hep B/C and syphilis
membranous GN
workup of membranous GN
hepatitis
cancer screens
tx of membranous GN
steroids
nephrotic disease seen in diabetics
diabetic glomerulosclerosis
lesions found on biopsy of diabetic glomerulosclerosis
Kimmelstiel-Wilson nodules
nephritic syndrome that occurs 2-3 days post infection
IgA nephropathy
nephrotic syndrome associated with Henoch-Schonlein purpura
IgA nephropathy
3 different presentations seen in IgA nephropathy
macroscopic hematuria
microscopic hematuria
high blood pressure
nephritic syndrome with normal C3 and C4 levels
IgA nephropathy
what is Henoch-Schonlein purpura
disease of children with IgA deposits in skin, GI, kidney and joints
clinical signs of Henoch-Schonlein purpura
lower extremity bruising
bloody diarrhea
hematuria and HTN
arthralgia
tx of Henoch-Schonlein purpura
supportive
nephritic disease that presents 2 - 3 weeks post infection
post-infectious GN
antigen is deposited where in post-infectious GN
subendothelium
C3 and C4 levels in post-infectious GN
low
test for post-infectious GN
ASO titer
treatment of post-infectious GN
none
nephritic syndrome that is usually caused by a secondary condition like sjogrens or SLE
membranoproliferative GN
nephritic syndrome with low C3 and normal C4
membranoproliferative GN
nephritic syndrome that is ANCA positive (Ig to type IV collagen)
anti-GBM/goodpastures
prognosis for anti-GBM/goodpastures
death if not treated
rapid onset of HTN
oliguria
anti-GBM/goodpastures
in goodpastures syndrome there is damage to both the kidney and the
lung (hemoptysis)
treatment for anti-GBM/goodpastures syndrome
steroids
plasmapheresis if pulmonary hemorrhage*
two types of small vessel vasculitis
Wegener's granulomatosis
microscopic polyangitis
decreased appetite
weight loss
hematruia
polymyalgia
small vessel vasculitis
antibodies present in Wegeners granulomatosis
c-ANCA
anti-PR3
antibodies present in microscopic polyangitis
c-ANCA
anti-MPO
acute onset of hematuria
proteinuria
edema
pancytopenia
lupus nephritis
antibodies present in lupus nephritis
anti-Sm
anti-DS DNA
classes of lupus nephritis that are treated
class III and above
treatment of lupus nephritis
steroids (class III and above)