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27 Cards in this Set

  • Front
  • Back
inflammation which is not immunotspecific and involves Neutrophils primarily
acute inflammation -

characterized by exudate - pus
what three cells are involved extensively in chronic inflammation which is immunotspecific
lymphocytes, plasma cells, macrophges
3 major evenst occuring in acute inflammation
Hemodynamic change
increased vascular permiabiilty
extravasation fo leukocytes
vessel changes in acute inflammation
increased blood flow to area of injury (redness)
vascular permeability (swelling)
"mopping up" in acute inflammation is primarily done by
PMNs, some macrophages
slowed flow near injury - so more conc of cells in vascular space which increases the chances that they will interact with EC
5 mechanisms of edema formation
1. increased hydrostatic
2. decreased blood oncotic
3. endothelial damage
4. dcreased lymphatic damage
5. Na+ retention by the kidnes
what is the differene between transudate and exudate
exudate is turbid and viscous (like pus)- it has many cells in it

Transudate is watery with few cells

NOTE: they both have the same spec. Grav, and protein content
4 families of adhesion moleculees
1. selectins
2. Immunoglobulin Superfamily (ICAM, VCAM)
3. Integrins
4. Glycoprotiens (bind selectins)
P Selectins bind
platelets and endothelium
E selectins bind
Endothelium (ESL-1 glycoprotein)
L selectins
bind Leukocytes

(CD34, glycam1)
selectins bind
Ig superfamily bind

ICAM-1 binds LFA-1, MAC-1

VCAM-1 binds a4B1 and 7
in the immunoglobulin gene superfamily and important for self aggregation and diapedesis
PECAM-1 binds CD31 on endthelial cells
exogenous chemoattractants
target derived

e.g bacterial lipids
endogenous chemoattractants
(host derived)

e.g chemokines (e.g C5a, LTB4, IL-8)
collectins are opsonins that bind what kind of leukocyte receptor
the C3b opsonin binds what on leukocyte
CR!, CR2, CR3 (Mac-1)
a bulla is what kind of inflammation
serous inflammation
pericarditis is what kind of inflammation
an abscess is what kind of inflammation
Hashimotos Thyroiditis and multiple sclerosis results in what kind of inflammation
three cells seen in Granuloma (dont count giant cells which are often, but not always present)
T cells, plasma cells, epitheloid histiocytes
four outcomes of inflammation
1. resolution
2. abscess formation
3. fibrosis (scar)
4. chronic inflammation
the two meanings of "chronic" - we use them both!
1. histpathological: lymphocytes, plasma cells, macrophages,
2. temporal: stays around for a long time

NOTE: any process of acute inflammation (w/PMNs) can become "temporally chornic" if it fails to resolve but this does not necessarily mean that it is histopathologically chronic (e.g staph aureus in AIDs patient) - slide 40
an abnormal connection or passageway between organs or vessels that normally do not connect.