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12 Cards in this Set
- Front
- Back
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Result of acid in duodenum
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Decreased vagal input
Increased SECRETIN production (decreased gastrin) LESS ACID |
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Result of sugars and fat in duodenum
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Increased CCK production (increased somatostatin)
LESS ACID |
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Result of distension of stomach or duodenum
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Increased vagal input
MORE ACID |
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Result of Proteins and amino acid in stomach or duodenum
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Increased gastrin production
MORE ACID |
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Result of smell, taste of food
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Increased vaguls
MORE ACID |
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Causes 75% of all peptic ulcer disease
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Helicobacter pylori infection
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Zollinger-Ellison Syndrome
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Gastrinoma
Increased gastrin = increased acid = peptic ulcer disease |
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Only curative treatment for gastrinoma
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Surgical resection
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Why do NSAIDS cause peptic ulcer disease
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Inhibit COX -1 which normally produces prostacyclines (increase mucosal blood flow, increase mucous and bicarbonate production, decrease acid production)
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Why does stress cause PUD
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Shunting blood away form the GIT for trauma, brain injury, etc. Alpha adrenergic mediated
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Misoprosterol
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Increases prostaglandin synthesis (increased mucous production)
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Sucralfate
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Binds to the base of peptic ulcers, protective (does not work very well)
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