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11 Cards in this Set
- Front
- Back
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Captopril 1st PO ACE inhibitor dysgeusia - common for thiols skin rash (4-7%) - allergies common for thiols Largely excreted in urine No sexual or intellectual impairment Take one hour before meals |
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Enalapril Prodrug (needs to be hydroylzed) Longer DoA than Captopril = BID No thiol group = no dysgeusia & no rash! |
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Lisinopril Cyclic and bulky group limits digestion via Carbodypeptidase in stomach No thiol group = no dysgeusia & no rash! No sexual or intellectual impairment |
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Benazepril Big cyclic structure mimics proline; acts at carboxy terminus --> Orally bioavailable Prodrug (needs to be acid to interact with Zn) Rapid onset; QD |
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Fosinopril Cascading prodrug No dose adjustment needed for renally impaired |
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Quinapril Prodrug Isoquinoline mimics proline |
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Ramipril Prodrug QD |
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Moexipril Need higher dose Take one hour before meals |
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Trandolapril Prodrug Orally bioavailable Extended half life --> increase in potency |
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Perindopril Prodrug |
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Agranulocytosis |
Drop in WBC count observed in patients receiving: Captopril, Enalapril, & Lisinopril |
