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12 Cards in this Set
- Front
- Back
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What are three proposed viral etiologies for Paget’s disease?
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Respiratory syncytial virus (RSV)
Paramyxovirus Canine distemper virus |
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What is the typical clinical presentation of Paget’s?
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Bone pain
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Within a given bone, how does Paget‘s progress?
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Starts at one end and progresses to the other
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What is the radiographic appearance of progression?
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Leading "lytic flame"
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Laboratory findings include increased levels of what four substances?
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Alkaline phosphate
Urinary hydroxyproline Osteocalcin N-telopeptide |
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What are the three key histologic features?
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Osteoclasts with viral inclusion bodies(paramyxovirus)
Cement lines Relative osteoblastic or osteoclastic appearance depends on phase of disease |
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What is the treatment of Paget’s disease?
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Bisphosphonates
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What other clinical conditions occur secondary to Paget’s disease in the spine?
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Spinal stenosis
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What other clinical conditions occur secondary to Paget’s disease in the heart?
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High output cardiac failure
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What other clinical conditions occur secondary to Paget's disease in the auditory system?
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Deafness
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What does the new onset of severe pain and swelling in a patient with known Paget’s suggest?
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Malignant osteosarcoma
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How often does this occur?
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In 10% of patients
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