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12 Cards in this Set
- Front
- Back
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What is the half-life of articular cartilage?
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117 years
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Because cartilage has such a long half-life, what is the rate of cartilage synthesis in adulthood?
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Markedly diminished relative to earlier in life
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What is the basic mechanism by which normal cartilage ages?
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Passive glycation
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What is the net effect of this process?
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Increased cartilage stiffness (modulus of elasticity)
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With aging, what changes are seen in chondrocyte number?
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Decreases
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What changes are seen in chondrocyte size?
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Increases
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What changes are seen in collagen variability?
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Increases
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What changes are seen in total proteoglycan concentration?
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Decreases
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What is the corresponding change in water content?
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Decreases
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In normal aging, what happens to chondroitin 4 concentration as a
percentage of total chondroitin? |
Decreases
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What happens to keratan sulfate concentration?
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Increases
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Again, what is the net effect on modulus of elasticity?
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Increased (increased cartilage stiffness)
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