Abo And Mns Bgs

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ABO and H Blood group systems

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Single most important blood group for selection and transfusion of blood

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ABO and H Blood group systems

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Found on many tissues, body fluids, RBCs, platelets, endothelial cells

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ABO and H Blood group systems

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Major consideration in solid organ and bone marrow transplantation

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H antigen

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biosynthetic precursor of both A and B antigen

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A1 and A2

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- most common ABO subtypes encountered in the blood bank

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A1 red cells

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agglutinates with the lectin Dolichos biflorus

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Type 2 chain oligosaccharide

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ABO antigen are usually expressed on

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chromosome 9q34

A and B glycosyltransferases

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ABO gene locus is located on _____________________and encodes the _________________

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ABO Antibodies

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- most important antibodies in transfusion medicine-

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3–6 months of age

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ABO antibodies weak or absent in the sera of New Borns until?

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5–10 y/0

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Adult levels of ABO antibodies are reached by

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Bombay phenotypes and para-bombay

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2 rare null phenotypes of abo and H blood group system

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Bombay phenotype(Oh)

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Neither AB nor H antigens are present on RBCs or in secretions

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Para-Bombay

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Few or no ABH antigens on RBCs with or without normal expression of ABH antigens in secretions and body fluids

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Anti-A1

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naturally occurring antibody found in the sera of some A2, A2B, and other weak A subtypes

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Anti-A1

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hemagglutinates A1 RBCs, but not A2 and other weak A phenotypes

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Anti-A1

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implicated in transfusion reactions and solid organ rejection

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MNS BLOOD GROUP SYSTEM

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- 2nd blood group system identified after ABO

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> 46 antigens

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Mns blood grouo consists of

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RBCs

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MNS blood grouo system expresed only on

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U-, Mk, En(a-)

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3 major types of MNS BGS

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U-

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Most common type of mns bgs exclussively in blacks

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Henshaw phenotype

En(a-) phenotype

MkMk phenotype

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Null phenotypes of MNS BGS

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Henshaw phenotype

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- Recombinant glycophorin B

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Henshaw phenotype

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can react weakly with some examples of human anti-U known as “U variants (S−s−Uvar)”

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En (a−) phenotype

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result of recombination bet glycophorin A and B genes

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Lepore-type A-B hybrid (exons A1-B2-B5)

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En (a−) phenotype is a result of recombination bet glycophorin A and B genes to form a

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MkMk phenotype

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- lacks all MNSs antigens, including En(a)

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Anti-M and –N

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- naturally occurring ( IgM isotype)-

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Anti-M and –N

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detected at RT saline agglutinins

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anti-M

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: commonly encountered antibody in the blood bank

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Anti-M and –N

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-clinically insignificant antibodies and only rarely cause hemolytic transfusion reactions or HDF

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Anti-S, -s, and -U

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- always clinically significant

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Anti-S, -s, and -U

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- antibodies of IgG isotype

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Anti-S, -s, and -U

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- reactive at 37° C

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Anti-S, -s, and -U

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-reactivity of anti-U is resistant to proteolytic digestion

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Anti-S, -s, and -U

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- Causes of hemolytic transfusion reactions and HDFN

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Anti-m and anti-n

Anti-S, -s, -U

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Mns BGS