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21 Cards in this Set
- Front
- Back
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What is the pathology of Giant Cell Tumor (osteoclastoma)?
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Epiphyseal end of the long bones, locally aggressive benign tumor often around distal femur or proximal tibial region
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What is the appearance on an xray of GCT?
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Double-bubble or soap-bubble appearance on xray
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What is the morphology of GCT?
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Spindle shaped cells with multinucleated giant cells
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What is the age group of GCT?
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20-40yo
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Is GCT benign or malignant?
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Benign
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What is the pathology of Osteochondroma?
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Mature bone with cartilaginous cap, commonly originates from long mataphysis
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What is the most common benign tumor of bone?
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Osteochondroma
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What is the age range of Osteochondroma?
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<25yo
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What is the pathology of Osteosarcoma?
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Metaphysis of long bones, around distal femur, proximal tibia
Forms elevation of the periosteum (Codman's triangle) |
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What is the age range of Osteosarcoma?
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10-20yo
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Is Osteosarcoma benign or malignant?
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Malignant and AGGRESSIVE
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What is the pathology of Ewing's Sarcoma?
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Anaplastic small blue cell malignant tumor
Onion skin appearance in bone Appears in diaphysis of long bones, pelvis, scapula, ribs |
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What is the translocation for Ewing's Sarcoma?
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t(11:22)
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Is Ewing's Sarcoma benign or malignant?
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Malignant and EXTREMELY AGGRESSIVE
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What is the age range of Ewing's Sarcoma?
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Boys <15yo
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What is the pathology of Chondrosarcoma?
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Cartilaginous tumor, expansile glistening mass within medullary cavity
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Is Chondrosarcoma benign or malignant?
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Malignant
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What is the age range of Chondrosarcoma?
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Men 30-60yo
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Where is Chondrosarcoma commonly found?
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Pelvis, spine, scapula, humerus, tibia, femur
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What is the pathology of Osteitis Fibrosa Cystic (von Reckinhausen disease of bone)?
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Bony manifestation of an endocrine disorder, caused by Hyperparathyroidism
"Brown" tumors in bone (cystic spaces lined by osteoclasts filled with fibrous stroma and blood) |
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What is Type 1A Pseudohypoparathyroidism (Albright's Hereditary Osteodystrophy)?
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PTH resistance at renal tubules --> low serum Ca and high PO
Low Ca = High PTH = excessive osteoclastic activity |
