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20 Cards in this Set
- Front
- Back
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What are the 3 known critical elements in the timing of secondary sexual maturation?
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-Adequete body fat
-Adequete sleep -Visual exposure to sunlight |
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What is the first event in female sex maturation at puberty? What age? What hormone responsible?
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-Breast budding
-10-11 yrs old -Estrogen |
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What typically follows thelarche; what hormone?
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SExual hair growth - androgens
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What happens after breast buds and hair growth? What hormone?
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Growth spurt - GH
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What follows the growth spurt? Age/hormone?
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Menarche
11.5-13 Estrogen |
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What hormone is responsible for adult breast development and sexual hair and by what age is this completed?
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Adult breasts - progesterone
Adult hair - androgens 16 |
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What are the 4 categories of pubertal development abnormalities?
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-Delayed sex maturation
-Incomplete sex maturation -Primary amenorrhea -Precocious puberty |
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What is Delayed sex maturation defined as?
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Failure to show thelarche by age 13
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What is the first step in evaluating any abnormality of pubertal development?
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Measure serum FSH/LH levels
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What do gonadotropin levels tell you?
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Whether it's hypothalamic or pituitary or gonadal.
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What are the 5 most common causes of delayed pubertal development?
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PIIIG
-Premature ovarian failure -Inadequete GnRH release -Inadequete FSH/LH -Inadequete body fat -Genital tract anomalies |
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3 conditions of premature ovarian failure:
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-Turner syndrome
-Long arm Ch' X deletion -Alkylating chemo |
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What is Kallman syndrome?
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Olfactory tract hypoplasia - leads to inadequete GnRH!
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What drug can decrease GnRH release?
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Marijuana
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What inhibits FSH/LH release in breast feeding women?
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Prolactin inhibition
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What is the main concern to worry about if estrogen levels are too high too early?
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Premature closure of growth plates
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What is the main concern if estrogen levels don't rise?
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Osteoporosis early
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What is the most common cause of inappropriate secretion of androgens or estrogens
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CAH - congenital adrenal hyperplasia of the 21-hydroxylase type
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What does 21-hydroxylase deficiency do to puberty in girls? Why?
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Pubic hair grows first, then axillary, and no breast development occurs - acucmulation of androgens.
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What is the medical therapy for CAH dt 21-hydroxylase defic?
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Hydrocortisone
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