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18 Cards in this Set
- Front
- Back
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What is the mechanism for Sulfonamides?
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PABA antimetabolites inhibit dihydropteroate synthase
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Are sulfonamides bactericidal or bacteriostatic?
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Bacteriostatic
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What are the uses for sulfonamides?
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G+, G-, Nocardia, Chlamydia, UTI
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What are the toxicities of sulfonamides?
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Hypersensitivity reactions, hemolysis if G6PD deficient, nephrotoxicity, photosensitivity
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What is the mechanism for Trimethoprim?
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Inhibits bacterial dihydrofolate reductase
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Is Trimethoprim bactericidal or bacteriostatic?
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Bacteriostatic
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What is the use for Trimethoprim?
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Used in combo with sulfonamides, used for UTI's, Shigella, Salmonella, Pneumocystis jirovecii, MRSA
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What are the toxicities for Trimethoprim?
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Megaloblastic anemia, leukopenia, granulocytopenia
Inhibit cell growth in bone marrow |
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What is the mechanism for Fluoroquinolones?
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Inhibits DNA gyrase
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Are Fluoroquinolones bactericidal or bacteriostatic?
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Bactericidal
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What can Fluoroquinolones NEVER be taken with?
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Antacids
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What are the 9 Fluoroquinolones?
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Ciprofloxacin
Norfloxacin Levofloxacin Ofloxacin Sparfloxacin Moxifloxacin Gatifloxacin Enoxacin Lecofloxacin |
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What is the clinical use of Fluoroquinolones?
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G- rods of urinary and GI tracts, strep pneumo
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What are the toxicities of Fluoroquinolones?
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Contraindicated in pregnancy and kids
May cause tendon rupture in people over 60yo Cartilage damage shown |
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What is the mechanism for Metronidazole?
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Forms free radical toxic metabolites in bacterial cell that damages DNA
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Is Metronidazole bactericidal or bacteriostatic?
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Bactericidal
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What does Metronidazole treat?
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GET GAP on the Metro
Giardia Entamoeba Trichomonas Gardnerella vaginalis Anaerobes (Bacteriodes, C. Diff) BELOW THE DIAPHRAGM h. Pylori |
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What is the reaction with Metronidazole and alcohol?
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Disulfiram-like reaction, HA, metallic taste
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