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26 Cards in this Set
- Front
- Back
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What is the mechanism for Aminoglycosides?
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Inhibit formation for initiation complex
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Are Aminoglycosides Bactericidal or Bacteristatic?
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Bactericidal
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What are the 5 Aminoglycosides?
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Gentamycin, Neomycin, Amikacin, Tobramycin, Streptomycin
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What do Aminoglycosides target?
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Severe G- Rod infections
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What are the 4 toxicities of Aminoglycosides?
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NNOT
Nephrotoxicity Neuromuscular blockade Ototoxicity Teratogen |
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What is the mechanism of Tetracyclines?
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Attaches to the 30s and prevents attachment of aminoacyl-tRNA
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Are tetracyclines bactericidal or bacteriostatic?
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Bacteriostatic
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What are the four tetracyclines?
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Tetracycline, Doxycycline, Demeclocycline, Minocycline
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What can you not take with tetracyclines?
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Milk
Antacids Iron containing preparations |
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What are Tetracyclines used for?
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Borrelia Burgdorferi, M. Pneumo, Rickettsia, Chlamydia
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What are the toxicities of Tetracycline?
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Discoloration of teeth
Contraindicated in pregnancy |
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What is the mechanism of Macrolides?
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Inhibit protein synthesis by blocking translocation, binds to 23s rRNA
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What are the three macrolides?
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Azithromycin, Clarithromycin, Erythromycin
ACE |
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What are macrolides used for?
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Atypical pneumonias (Mycoplasma, Chlamydia, Legionella)
STD's (Chlamydia) G+ cocci (strep infections in pts allergic to penicillins) |
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What are the toxicities for macrolides?
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MACRO
Motility issues Arrhythmia from prolonged QT acute Cholestatic hepatitis Rash eOsinophila |
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Are macrolides safe in pregnancy?
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YES
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What is the mechanism for Chloramphenicol?
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Blocks peptidyltransferase at 50s
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Is Chloramphenicol bactericidal or bacteriostatic?
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Bacteriostatic
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What is Chloramphenicol used for?
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Meningitis (H. Influenzae, Neisseria Meningitidis, Strep pneumo)
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What are the toxicities of Chloramphenicol?
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Anemia, aplastic anemia, GRAY BABY SYNDROME (lack of liver UDP-glucuronyl transferase)
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What is the mechanism for Clindamycin?
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Blocks peptide transfer at 50s
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Is clindamycin bactericidal or bacteriostatic?
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Bacteriostatic
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What is the clinical use of Clindamycin?
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ANAEROBIC INFECTIONS
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What are the two drugs that treat ANAEROBES?
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Clinda + Metro
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What is the difference between Clinda and Metro in regards to anaerobes?
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Above diaphragm - Clinda
Below diaphragm - Metro |
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What is the toxicity of Clindamycin?
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Pseudomembranous Colitis, fever, diarrhea
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