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41 Cards in this Set

  • Front
  • Back
What will GC do in relation to stress?
Inc: gluconeogenesis
glycogen synthesis
BG
catbolism (breakdown)
How are GC anti-inflammatory?
Dec. leukocytes, cytokine, chemokines, macrophage and COX II expression
Long duration GC
Betamethasone
Dexamethasone
2 MC
fludrocortisone
desoxycorticosterone
Chronic AC insufficiency
Addison's disease
Treatment for Addisons or congenital adrenal hyperplasia
hydrocortisone (GC)
fludrocortison (MC)
What is the treatment for Cushings
surgery
irradiation
large dose cortisol->reduced dose
Treatment for aldosteronism
Spironolactone
What can be given IM maternall to inc. fetal lung maturation
betamethasone
What kind of diet should someone with GC toxicity be on?
high protein
high potassium
GC are contraindicated in what populations?
PUD heart disease
CHF Infxn
Psych DM
Osteo glaucoma
Precursor to aldosterone
deoxycorticosterone
Most commonly used MC
fludrocortisone
Drugs that inhibits synthesis of cortisol and used to test adrenal fxn
Metyrapone
Antifungal that inhibits adrenal and gonadal steroid
ketoconazole
Anti-progestin and GC, will reverse cushingoid effects
Mifepristone (RU486)
Competes with aldosterone sites
Spironolactone
Aldosterone antoagonist used to treat HTN
Eplerenone
3 endogenous estrogens
estradiol
estrone
estriol
4 estrogens, not estradiols
DES
Quinestrerol
Chlorotrianisene
Methallenestril
2 clinical uses of estrogen
1* hypogonadism
ERT
If woman had hysterectomy-how do you prescibe HRT?
can use estrogen alone
What kind of cancer does progestin prevent
Endometrial
Where is progesterone synthesized
ovary
testes
adrenals
placenta
Effects of progesterone
Inc. lipoprotein lipase -> inc. fat deposition

maturation of endometrium after ovulation
Competitive partial estrogen agonist used to treat breast Ca post menopause
tamoxifen
Partial estrogen agonist prevent post menopausal osteroporosis
raloxifene
Partial estrogen agonist that induces ovulation
Clomiphene
Weak progestin, androgen, & GC suppresses ovaries
Danazol
Testosterone is converted to dihydrotestosterone by what?
5 alpha reductase
Drug that inhibits 5 alpha reductase-used for BPH, male pattern baldness, hirsutism
Finasteride
4 Androgen RH analogs
Goserelin
nafarelin
Buserelin
Leuprolide
Drug used to treat excessive libido, female hirutism
Cyproterone
Sub Q rDNA PTH used to treat osteoporosis
Teriparatide
Vit D first hydroxylated in the liver to form
Calcifediol
25 OH vit. D further converted in the kidney to
Calcitriol
Hormone secreted by thyroid to decrease calcium concentration
Calcitonin
How do GC effect calcium?
Antag. Vit. D intestinal transport by stim. renal excretion of Ca++
Group of drugs that inhibit bone resorption. Treat Paget's and osteoporosis
Biphosphonates
Etidronate
Pamidronate
Alendronate
Risedronate
Tiludronate
Zoledronate
s/s hypocalcemia
tetany
laryngospasm
muscle cramps
convulsions
Drug that protects against spine fractures, but not hip
Raloxifene