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20 Cards in this Set
- Front
- Back
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MoA of Cyclophosphamide
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Cytotoxic alkylating agent
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MoA of Dapsone
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It's a mystery
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MoA of Glucocorticoids in Immunosuppressant capacity (3)
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- Affect neutrophil trafficking
- Decrease MP function - Decrease lymphocyte activity |
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MoA of methotrexate
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Inhibits folic acid reductase
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MoA of Azathioprine
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Purine antagonist
- Anti-metabolite |
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MoA of mycophenolate
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Purine antagonist
- Anti-metabolite |
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MoA of Cyclosporine
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Calcineurin inhibitor
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MoA of Tacrolimus
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Calcineurin inhibitor
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Toxicity of Tacrolimus
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- Gingival HS
- GI effects |
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Toxicity of Cyclosporine
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- Gingival HS
- GI effects |
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Toxicity of Cyclophosphamide (4)
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- Teratogen
- Myelosuppression - Cytotoxicity - GI effects |
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Toxicity of Dapsone
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Myelosuppression
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Toxicity of Glucocorticoids (4)
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- Induction of parturition
- Abortion - Congenital anomalies - Hyperadrenocorticism |
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Toxicity of Methotrexate (3)
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- Renal tubular necrosis
- Hematopoietic toxicity - GI effects |
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Toxicity of Azothioprine (2)
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- Myelosuppression
- GI effects |
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Toxicity of Mycophenolate (2)
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- Myelosuppression
- GI effects |
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What does purine antagonism affect?
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Decreases lymphocyte production
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What does Calcineuron inhibition affect?
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No calcineurin --> no NFAT --> No cytokines --> inhibits T-cell signalling function
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What does inhibition of folic acid reductase affect?
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Affects production of purines and pyrimidines
Also prevents reduction of Dihydrofolate to tetrahydrofolate |
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Four anti-proliferative immunosuppressive drugs
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- Cyclophosphamide
- Methotrexate - Azathioprine - Mycophenolate |
