2Vm - Pharmacology - Drugs (Diuretic & Urinary Drugs)

Front 1

8 diuretics we need to worry about

Back 1

- Acetazolamide
- Mannitol
- Furosemide
- Chlorothiazide
- Hydrochlorothiazide
- Triamterene
- Amiloride
- Spironolactone

Front 2

What drug is a Carbonic Anyhydrase inhibitor?

Back 2

Acetazolamide

Front 3

What drug is an osmotic diuretic?

Back 3

Mannitol

Front 4

What drug is a loop diuretic?

Back 4

Furosemide

Front 5

Two drugs that are thiazide diuretics

Back 5

Chlorothiazide
Hydrochlorothiazide

Front 6

Two drugs that inhibit renal epithelial Na+ channels

Back 6

- Triamterene
- Amiloride

Front 7

What drug is an aldosterone (mineralcoritcoid) inhibitor?

Back 7

Spironolactone

Front 8

MoA of acetazolamide

Back 8

Inhibit carbonic anhydrase

Front 9

MoA of Mannitol

Back 9

Increases osmotic pressure by being poorly reabsorbed in the nephron

Front 10

MoA of Furosemide

Back 10

Inhibits Na-K-2Cl symport

Front 11

MoA of Chlorothiazide

Back 11

Inhibts Na-Cl Symport

Front 12

MoA of Hydrochlorothiazide

Back 12

Inhibts Na-Cl Symport

Front 13

MoA of Triamterene

Back 13

Inhibit renal Na+ channel
K+ sparing

Front 14

MoA of Amiloride

Back 14

Inhibit renal Na+ channel
K+ sparing

Front 15

MoA of Spironolactone

Back 15

- Aldosterone antagonist
- K+ sparing
- Bind to MR and facilitate release of HSP90

Front 16

Site of Action (SoA) of Acetazolamide

Back 16

Proximal tubule

Front 17

Site of Action (SoA) of Mannitol

Back 17

Loop of Henle (TAL)

Front 18

Site of Action (SoA) of Furosemide

Back 18

TAL

Front 19

Site of Action (SoA) of Chlorothiazide

Back 19

* Distal convoluted tubule

Front 20

Site of Action (SoA) of Hydrochlorothiazide

Back 20

* Distal convoluted tubule

Front 21

Site of Action (SoA) of Triamterene

Back 21

Late distal tubule
Collecting duct

Front 22

Site of Action (SoA) of Amiloride

Back 22

Late distal tubule
Collecting duct

Front 23

Site of Action (SoA) of Spironolactone

Back 23

Late distal tubule
Collecting duct

Front 24

Drug that acts at the proximal tubule

Back 24

Acetazolamide

Front 25

Drug that acts on the TAL (2)

Back 25

- Mannitol
- Furosemide

Front 26

Drug that acts on the distal convoluted tubule (5)

Back 26

- Chlorothiazide
- Hydrochlorothiazide
- Triamterene
- Amiloride
- Spironolactone

Front 27

Drug that acts on the collecting duct (3)

Back 27

- Triamterene
- Amiloride
- Spironolactone

Front 28

What ionic effect do Carbonic Anyhdrase inhibitors have?

Back 28

Reduces NaHCO3 reabsorption

Front 29

What's the ionic effect of osmotic diuretics?

Back 29

Reduces NaCl reabsorption

Front 30

What's the ionic effect of Loop diuretics?

Back 30

Increase Na, Cl, K excretion

Front 31

What's the ionic effect of Thiazide diuretics?

Back 31

Reduces NaCl reabsorption

Front 32

What's the ionic effect of Renal epithelial Na+ channels? (2)

Back 32

Decreases NaCl reabsorption
Increases K+ retention

Front 33

What's the ionic effect of aldosterone inhibitors? (2)

Back 33

Decreases NaCl reabsorption
Increases K+ retention

Front 34

What drug acidifies the urine?

Back 34

Ammonium Cl-

Front 35

What drug alkalinizes the urine?

Back 35

Potassium Citrate

Front 36

What urinary affect does atropine have?

Back 36

Increases urinary retention

Front 37

What urinary affect does bethanechol have?

Back 37

Stimulates bladder contraction

Front 38

What urinary affect does dantrolene have?

Back 38

Relaxes external urinary sphincter

Front 39

What urinary affect does diazepam have?

Back 39

Increases urinary retention by relaxing detrusor m.

Front 40

What urinary affect does Phenoxybenzamine have?

Back 40

Increases urinary excretion by blocking a1 actions on internal urinary sphincter

Front 41

What urinary affect does phenypropanolamine have?

Back 41

Increases urinary retention by:
- Relaxing detrusor m.
- Increasing internal urinary sphincter tone