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37 Cards in this Set
- Front
- Back
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Three actions of glucocorticoids
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- Metabolism of COH, CNH, Fats
- Maintenance of microcirculation - Development of fetal pulmonary surfactant |
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2 things mineralcorticoids are involved with
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- Fluid homeostasis
- Increasing aldosterone |
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3 things increased aldosterone does
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- Na+ retention
- K+ excretion - CNH excretion |
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5 accepted uses of glucocorticoids
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- Endocrine replacement
- Anti-inflammatory - Anti-allergenic - Therapy of shock - Immunosuppressive |
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3 not accepted uses of glucocorticoids
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- Laminitis
- Snake bite - Lack of appetite |
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2 mechanisms of action of glucocorticoids
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- Genomic
- Non-genomic |
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3 genomic actions of glucocorticoids
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- Inhibit pro-inflammatory transcription factors
- Suppressing transcription of inflammatory genes - Induce transcription of immunosuppressive genes |
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3 non-genomic actions of glucocorticoids
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- Those associated with cGCR
- Those associated with mGCR - Non-specific effects caused by interactions with cellular membranes |
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4 specific MoAs of glucocorticoids
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- Bind receptor in cytosol, then migrate to nucleus
- Block NF-k-B - Induce annexin 1 to inhibit ARA release - Non-genomic activation of anti-inflammatory proteins |
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What do glucocorticoids induce?
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Glycogen synthase
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What do glucocorticoids antagonize?
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ADH
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5 short acting glucocorticoids
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Hydrocortisone
Cortisone Prednisone Prednisolone Methylprednisolone |
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1 intermediate acting glucocorticoids
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Triamcinolone
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3 long acting glucocorticoids
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Flumethasone
Dexamethasone Betamethasone |
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Most important post-treatment AE to consider with glucocorticoids
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Shut down of endogenous glucocorticoid production
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HPAA suppression of short acting glucocorticoids
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+
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HPAA suppression of intermediate acting glucocorticoids
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++
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HPAA suppression of long acting glucocorticoids
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+++
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Mineralcorticoid potency of intermediate acting glucocorticoids
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0
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Mineralcorticoid potency of long acting glucocorticoids
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0
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Mineralcorticoid potency of Hydrocortisone
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++
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Mineralcorticoid potency of Cortisone
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++
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Mineralcorticoid potency of prednisone
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+
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Mineralcorticoid potency of prednisolone
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+
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Mineralcorticoid potency of methylprednisolone
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+
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Glucocorticoid stimulation factor in comparison to hydrocortisone of cortisone
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0.8
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Glucocorticoid stimulation factor in comparison to hydrocortisone of prednisone
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4
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Glucocorticoid stimulation factor in comparison to hydrocortisone of prednisolone
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4
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Glucocorticoid stimulation factor in comparison to hydrocortisone of methylprednisolone
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5
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Glucocorticoid stimulation factor in comparison to hydrocortisone of triamcinolone
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5
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Glucocorticoid stimulation factor in comparison to hydrocortisone of flumethasone
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15
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Glucocorticoid stimulation factor in comparison to hydrocortisone of dexamethasone
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30
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Glucocorticoid stimulation factor in comparison to hydrocortisone of betamethasone
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30
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4 structural groups that are important for glucocorticoid function
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- Keto group
- 4,5 double bond - 11 OH group - a-hydroxal group |
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2 chemical alterations that reduce mineralocorticoid activity
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- Methylation
- Fluorination |
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1 group that's essential for mineralocorticoid activity
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21 OH group
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4 CIs of Glucocorticoids
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- Infections
- Corneal ulcers - GI ulcers - Hyperadrenocorticism |
