9.4A Pathophysiology - Hematologic Function

Front 1

Classify the anemia type:

(description) - large size, normal color
(patho) - cells are megoblastic (premitive/juvenile)
(examples)- decreased folic acid
- pernicious anemia

Back 1

Macrocytic, Normochromic

Front 2

Classify the anemia type:

(description) - normal size, normal color
(patho) - decreased number of cells
(examples) - Loss of RBCs (hemorrhage)
- Increased RBC destruction (Splenomegaly, excessive immune response, Sickle Cell, G6PD Deficiency)
- Decreased Production (Anemia of Chronic Disease, Aplastic Anemia, Most hemolytic anemias)

Back 2

Normocytic, Normochromic

Front 3

Classify the anemia type:

(description) - small size, pale
(patho) - not enough, deficient production
- hemoglobin is problem
(examples) - Alpha & Beta Thalassemias
- Iron Deficiency

Back 3

Microcytic, Hypochromic

Front 4

Describe RBC life cycle: (six steps)

Back 4

1. leave bone marrow when mature, circulate ~ 120 days
2. Need folic acid & B12 to mature
3. Liver & Spleen remove old RBCs
4. Recycled as ferritin
5. Carried by transferrin
6. Heme converted to bilirubin

(14 g/mL hgb in blood)

Front 5

What is bleeding time?
(measure of time from small puncture wound to formation of platelet plug)

Back 5

- Normal 3-8 min.
- Abnormal 10 min.

Front 6

Partial Thromboplastin Time (PTT)

Thromboplastin I
Prothrombin -------------------------- Thrombin

Back 6

Measures activity of coagulation factors including thromboplastin.

Normal - < 35 seconds

Front 7

What is the normal platelet count?

Back 7

~ 150,000/mm^3 - 400,000/mm^3

Front 8

What are the leukocyte percentages?

What is the avg. concentration of WBCs in the blood?

Back 8

Neutrophils 55-70%
Lymphocytes 20-40%
Monocytes 2-8%
Eosinophiles 1-4%
Basophiles .5-1%

4.8-10.8x10^3 /L

Front 9

Determines activity of coagulation factors including factor II.

Back 9

Prothrombin Time

Front 10

What is the normal Prothrombin Time?

Back 10

Normal 12-15 sec.
Abnormal > sec.