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12 Cards in this Set
- Front
- Back
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Name some GABA receptor antagonists
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Lindane, Toxaphene, Cyclodienes, and Fipronil
"convulsants" |
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What keeps GABA open
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Benzodiazepines, barbituates
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How do barbituates work?
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"the latch mechanism" of barbituate action keeps the channel in the open position
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How are hexachlorocyclohexanes synthesized?
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Know that gamma isomer (lindane) is insecticidal and only the beta isomer is persistent in the ecosystem and body fat.
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What are important properties of lindane and what is it used for?
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unstable in alkali and readily metabolized (volatized)
Lindane used in shampoo for head lice Easy manufacture and low cost |
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Why was BHC banned and lindane restricted?
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Oncogenicity
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What cyclodiene is currently important and what are its properties?
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Endosulfan- important now- contains sulfur and less stable
Use in cotton- resistance a major problem |
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Describe cyclodienes' toxicology!
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Toxic to bees, pollinators, not very specific
Mammalian tox- attack CNS with convulsion, high dermal tox, liver damage 1-10ppm- carcinogenic Persistence and environmental aspects- accumulate in fat, into milk, less biomag than DDT- slowly metabolized |
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What are a few properties of fipronil?
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Broad spectrum, highly toxic to bees and fish, analog is ethiprole
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Do avermectins open or close the GABA-gated chloride channels (agonist)?
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Stimulate the release of GABA causing paralysis agonist
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What is the specificity of Acaricides?
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They control mites and ticks but do not effect insects and have low mammalian toxicity
Fungicide activity |
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What is Dicofol an analog of?
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DDT with (OH)
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