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19 Cards in this Set
- Front
- Back
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Vincristine
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made from periwinkle plant
blocking tubulin from forming microtubules = inhibits mitosis |
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Methotrexate
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inhibits dihydrofolate reductase
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Purimethol other name?
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6 MP
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Dacarbazine
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alkylating agent
highyly emetogenic so must be pre medicated |
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Mechlorethamine
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alkylating agent
extreme BMD extensive blisters if extravasated on the skin |
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Procarbazine
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inhibits both DNA & RNA
Disulfuram reactions and neurotoxicity |
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cyclophosphamide side effect
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hemmorhagic cystitis that may progress to bladder fibrosis
alkylating agent so can cause secondary cancers |
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Bleomycin SE
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pulmonary fibrosis
originally an antibiotic |
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Ciplatin
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Cisplatin --> ceases all RNA and DNA synthesis
causes interstrand cross linking bt nucleotides persistant, intractable vomiting, nephrotoxicity, ototoxicity and PERIPHERAL NEUROPATHY DOC-testicular and bladder cancer |
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L-asparaginase SE
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Hypersensitivity!!
"allergic to asparagus" |
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Doxorubicin SE
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cardiac toxicity=dilated cardiomyopathy
red urine |
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Leuprolide
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prostate cancer treatment
hot flashes |
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Flutamide
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prostate cancer treathment
gynocomastia |
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Tamoxifen
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estrogen receptor modulator works but inhibit estrogen specifically in breast tissue
prophylactically in women at high risk |
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NSAIDS 3 major fuctions
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1-decrease pain
2-decrease inflammation 3-decrease fever all via inhibition of cyclooxygenase |
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Aspirin
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IRREVERSIBLY inhibts cyclooxygenase
works at periphery and at thermoregulatory centers in hypothalamus = decrease inflammation and fever NEVER w/ gout bc competes w renal transport of getting uric acid out of the system |
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Acetaminophen
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NO peripheral anti inflammatory action so not truly and NSAID
DOC- kids w/ virus |
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Indomethacin
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BIG GUN
powerful anti-inflammatory and mostly reserved for certain severe instances such as gouty arthritis, ankylosing spondylitis, and osteoarthritis of the hip (really good in anti inflam actions) toxicity limits use :GI distubance, ulceration that may perforate and hemorrhage. Rarely-pancreatitis, fatal hepatitis, aplastic anemia |
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COX-2 inhibitors-Celecoxib
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selectively inhibit COX 2 the from of cox responsible for catalyzing the formation of PG in inflamm or injurous states
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