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11 Cards in this Set
- Front
- Back
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BM vs SC Transplant
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BM Transplant: SCs from BM (BM harvest)
SC Transplant: SCs from Periphery (either peripheral stem cells or marrow) |
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Autologous vs Allogeneic Transplant
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Autologous: high dose chemo w/SC rescue
Allogeneic: uses SCs from a donor after chemotx (there are multiple types!) |
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What is the most important factor in determining compatibility among donors?
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HLA Type
NOT BLOOD TYPE |
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Transplant guidelines (donors):
Age Sex Pregnancy |
Older donors-->higher risk to pt (have more Ags)
Men > Women Nulliparous women > Multiparous women |
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What is the Graft v Leukemia Effect?
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New T-cells from donor act as surveillance system against recurrence of malignancy.
If there's early relapse of leukemia, can remove immunosuppression to stimulate graft-versus-leukemia effect. |
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What is Graft v Host disease?
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When T-cells from donor attacks native organs on recipient (skin, gut, oropharynx)
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Risks of transplant:
Within 100 days After 100 days |
Within 100 days: infection
Post 100 days: recurrence of dz |
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Which transplant exhibits both Graft v Leukemia and Graft v Host?
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Allogeneic; it's someone else's immune system.
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What is the average hospitalization for transplantation?
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4 weeks
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Which cancers are eligible for autologous transplant?
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-Relapsed Hodgkins and Non-Hodgkins
-De novo good risk ALL -MM -Good risk AML |
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Which cancers are eligible for allogeneic transplant?
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AML, CML
ALL, CLL MDS Aplastic anemia Chemotx refractory disease |
