Isolated cardiac sarcoidosis- An autopsy case report
Abstract: Sarcoidosis is a systemic disease of uncertain etiology, characterized by non- caseating epitheloid cell granulomas which can virtually involve any organ. Cardiac involvement of sarcoidosis is seen in around 4-5% patients, while autopsy studies proved incidence up to 20-25%. Sudden cardiac death is common in cardiac sarcoidosis, since it was not diagnosed due to silent clinical presentation. We report a case of cardiac sarcoidosis in a 43 years patient, who presented with chest pain and succumbed to sudden death. Autopsy revealed heart showing gross and histopathological findings of sarcoidosis, thus confirmed the diagnosis.
Key words: Cardiac sarcoidosis, …show more content…
The quoted incidence of clinical heart involvement is around 4-5% while at autopsy at least 20-25% patients show cardiac sarcoidosis and 13-25% deaths occur from the disease. (1) Cardiac sarcoidosis occurs more frequently in young adults. (2) The clinical presentation can vary from benign ectopic to life threatening arrhymias. The diagnosis of cardiac sarcoidosis is often difficult since patients remain clinically silent and cardiac dysfunction is the only sign. The outcome of most of the patients that are not diagnosed in time is sudden death. (3)
Case report: We report a case of cardiac sarcoidosis in a 43 years male patient who presented with chest pain and succumbed to sudden death. Viscera were sent for histopathological examination. Grossly the heart was weighing 300 grams and there were multiple whitish fibrotic areas distributed all around the inter- ventricular wall, myocardium of left ventricle wall (fig 1). Multiple sections were processed from affected area. Microscopy revealed multiple non- caseating granulomas comprised of epitheloid cells, lymphocytes and giant cells (fig2). Asteroid bodies also seen (fig
Abstract: Sarcoidosis is a systemic disease of uncertain etiology, characterized by non- caseating epitheloid cell granulomas which can virtually involve any organ. Cardiac involvement of sarcoidosis is seen in around 4-5% patients, while autopsy studies proved incidence up to 20-25%. Sudden cardiac death is common in cardiac sarcoidosis, since it was not diagnosed due to silent clinical presentation. We report a case of cardiac sarcoidosis in a 43 years patient, who presented with chest pain and succumbed to sudden death. Autopsy revealed heart showing gross and histopathological findings of sarcoidosis, thus confirmed the diagnosis.
Key words: Cardiac sarcoidosis, …show more content…
The quoted incidence of clinical heart involvement is around 4-5% while at autopsy at least 20-25% patients show cardiac sarcoidosis and 13-25% deaths occur from the disease. (1) Cardiac sarcoidosis occurs more frequently in young adults. (2) The clinical presentation can vary from benign ectopic to life threatening arrhymias. The diagnosis of cardiac sarcoidosis is often difficult since patients remain clinically silent and cardiac dysfunction is the only sign. The outcome of most of the patients that are not diagnosed in time is sudden death. (3)
Case report: We report a case of cardiac sarcoidosis in a 43 years male patient who presented with chest pain and succumbed to sudden death. Viscera were sent for histopathological examination. Grossly the heart was weighing 300 grams and there were multiple whitish fibrotic areas distributed all around the inter- ventricular wall, myocardium of left ventricle wall (fig 1). Multiple sections were processed from affected area. Microscopy revealed multiple non- caseating granulomas comprised of epitheloid cells, lymphocytes and giant cells (fig2). Asteroid bodies also seen (fig