Pain may also develop for reasons completely unrelated to the underlying disease; thus, abdominal pain in patients with ADPKD may be a diagnostic challenge.
In addition to pain, other physical symptoms that patients with early-stage ADPKD may report include fatigue, breathlessness, weakness, and malaise.[24]
Hematuria
Hematuria frequently is the presenting manifestation and usually is self-limited, lasting 1 week or less. Polycystic kidneys are unusually susceptible to traumatic injury, with hemorrhage occurring in approximately 60% of individuals. Mild trauma can lead to intrarenal hemorrhage …show more content…
In ADPKD, the hypertension is usually more severe early in the course of the disease and becomes less problematic as the renal insufficiency progresses. A rise in diastolic blood pressure is the rule in ADPKD.
Palpable, bilateral flank masses occur in patients with advanced ADPKD. Nodular hepatomegaly occurs in those with severe polycystic liver disease.
Symptoms related to renal failure (eg, pallor, uremic fetor, dry skin, edema) are rare upon …show more content…
The prevalence of hypertension increases with age, with a rate of approximately 85% when patients enter ESRD.
Polycystic liver disease
The presence of cysts in the liver, pancreas, and spleen is a well-known feature of polycystic liver disease, which is a frequent extrarenal manifestation of ADPKD.[9]Pain and infection are the only symptoms that occur from the presence of hepatic cysts. Most frequently, cysts are asymptomatic.
Polycystic liver disease belongs to a family of liver diseases characterized by an overgrowth of biliary epithelium and supportive connective tissue. It is characterized by multiple cysts that may be microscopic or can occupy most of the abdominal cavity. Liver size may range from normal to enlarged.
Women are more likely to have more and larger hepatic cysts than men; this correlates with estrogen exposure and increases with gravidity in women. Liver size in massive polycystic liver disease tends to stabilize after menopause. Hepatic cysts occur in almost 50% of affected patients. Cysts occur in approximately 20% of patients during the third decade of life and in 75% during the seventh decade of life. They are rare in children, and the frequency increases with age. Pancreatic cysts occur at a rate of 9% in patients older than 20