Reading...
Play button
Play button
Use LEFT and RIGHT arrow keys to navigate between flashcards;
Use UP and DOWN arrow keys to flip the card;
H to show hint;
A reads text to speech;
20 Cards in this Set
- Front
- Back
|
Vmax is proportional to?
|
Enzyme concentration
|
|
|
Increased X-intercept will effect what?
Increased Y-intercept will effect what? |
Increased Km
Decrease Vmax |
|
|
Km = [S] when?
|
@ 1/2 Vmax
|
|
|
INHIBITORS
- which ones can be overcome with increased [S] |
- Competitive inhibitors
|
|
|
INHIBITORS
- which ones bind to active site? - why? |
- Competitive inhibitors
- b/c they resemble substrate |
|
|
COMPETITIVE INHIBITORS
- effects on Vmax - effects on Km - effects on PharmacoDynamics |
- No change
- Increases - Decreases Potency |
|
|
NON-COMPETITIVE INHIBITORS
- effects on Vmax - effects on Km - effects on PharmacoDynamics |
- Decreases
- No change - Decreases Efficacy |
|
|
Vmax is Unchanged with what inhibitors?
Km is Unchanged with what inhibitors? |
- Competitive inhibitors
- Noncompetitive inhibitors |
|
|
Volume of Distribution (Vd) equation?
|
(Amount of Drug in Body)
= -------------------------------------------- (Concentration of Drug in Plasma) |
|
|
A drug infused as constant rate requires how many half lives to reach Steady State?
|
4 to 5 half lives
|
|
|
Based on 1st Order Elimination,
Concentration of drug @: - 1 half life - 2 half life - 3 half life - 4 half life |
- 50%
- 75% - 87.5% - 93.75% |
|
|
Loading Dose (LD) equation
|
= Cp x Vd/F
Cp = Plasma Concentration Vd = Volume of Distribution F = Bioavailability |
|
|
Maintenance Dose (MD) concentration
|
= Cp x CL/F
Cp = Plasma Concentration CL = Elimination Rate F = Bioavailability |
|
|
In renal or liver diseases
- Maintenance Dose (MD) changes how? - Loading Dose (LD) changes how? |
- Decreases
- Unchanged |
|
|
Bioavailability (F) = 1 when?
|
- when Drug is given IV
|
|
|
Half Life equation = ?
|
= 0.7 x Vd / CL
Vd = Volume of Distribution CL = Clearance |
|
|
Clearance (CL) equation ?
|
= Vd x Ke
Vd = Volume of Distribution Ke = Elimination Constant (or rate of drug elimination divided by plasma drugs concentration) |
|
|
ZERO-ORDER ELIMINATION
- Rate of Elimination is ____ with time - Cp changes how with time? |
- Linear
- Decreases Constantly with time |
|
|
FIRST ORDER ELIMINATION
- Rate of Elimination is _____ with time - Cp changes how with time? |
- Proportional to Drug Concentration
- Decreases Exponentially with time |
|
|
Name 3 Zero Order Elimination Drugs
|
(PEA is shaped like a Zero)
- Phenytoin - Ethanol - Aspirin (at high/toxic doses) |
