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28 Cards in this Set
- Front
- Back
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Distribution of Zinc in the body varies from
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1.5-2.5g
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Most Zinc is found in the
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muscles and bone but is not available there
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Primary form of zinc is as an
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intracellular ion
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Zinc has three functions as a
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catalytic, structural, and regulatory mineral
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Zn must first be
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hydrolyzed
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the best source of Zn are
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animal sourse, oysters
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Zn enters the
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brush border and THEN cytosol THEN binds to metallothionein (zinc pool)
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metallothionein acts as an
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explandable Zn pool & NOT as a transporter, it regulates further Zn absorbtion
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To enhance Zn Absorbtion
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deficient (like all nutrients), pregnant, lactating, and human milk better abosrbtion, animal sources
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to inhibit Zn absorbtion
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phylate, oxalate and fiber, high dose of Ca, Fe is supplemented, Cu supplementation
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major route for excretion is
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feces
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with normal intake about
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80% of intake will end up in feces
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the catalytic function of Zn is to
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carbonic anhydrase in acid-base balance, DNA polymerase
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Zn is needed for
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growth
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Zn is needed structuraly for
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stabilizing biomembranes and help proteins fold up ZN FINGERS
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Zn is needed in regulatory purposes for
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stimulator of trans-acting factors that regulate gene expression
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Zn fingers motives
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enable small polypeptides to fold into more stable configuration by binding with Zn
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average nutrient density for a mixed diet is
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5.1 mg Zn/1000kcal
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mild Zn deficiency leads to
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imparied immune function and wound healing, dematitis, sore throat
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severe Zn deficiency leads to
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all teh above plus anorexia (from loss of taste), dwarfism, hypogonadism, and nigh blindness
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The inherited disease in which the body does not produce enzyme to shuttle Zn across intestine is
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Acrodermatitis Enteropathica
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Acromodermatits Enteropathica is treated with
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large oral doses of Zn
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Zn toxicity is rare but can occur when
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food is prepared in galvanized containers or when Zn is inhaled
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High doses of Zn can interfere with
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Fe and Cu absorbtion
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Zn status can be assesed by
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WBC Zn levels, light dark test, metallothionen and serum zinc
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metallothionen levels ______ during deficency
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decrease
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Zn along with vitamin A are used in
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light-dark adaptation
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the At risk population for Zn def. are
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anorexia, poor food choices, low protein dies and strict vegetarians
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