Reading...
Play button
Play button
Use LEFT and RIGHT arrow keys to navigate between flashcards;
Use UP and DOWN arrow keys to flip the card;
H to show hint;
A reads text to speech;
46 Cards in this Set
- Front
- Back
|
T-cell activation inhibiting costimulatory molecule...
|
CTLA-4 - B7
|
|
|
T-cell activation activating costimulatory molecule...
|
CD28 - B7
|
|
|
class I MHC - CD*** T*** cells
class II MHC - CD*** T*** cells |
8+ Tc
4+ Th |
|
|
HEL mice undergo central tolerance deletion/receptor editing of *** in the ***.
|
B cells
bone marrow |
|
|
CD28 is expressed by ***.
|
both resting & activated T cells
|
|
|
CTLA-4 is expressed by ***.
|
activated T cells
|
|
|
Both B7 molecules are expressed on ***, ***, and ***.
|
dendritic cells, activated macrophages, and activated B cells
|
|
|
Treg cells in the *** and *** can induce PT.
|
secondary lymphoid tissue
sites of inflammation |
|
|
CD25 is also known as...
|
IL-2R α chain
|
|
|
Normally TSH is produced by the ***.
|
pituitary gland
|
|
|
Autoimmune disease can be caused by...
1)*** 1)*** 3)*** |
1) release of sequestered antigens
2) molecular mimicry 3) inappropriate class II MHC expression |
|
|
DTH?
*** *** |
Type IV hypersensitivity
Delayed Type Hypersensitivity(IV) |
|
|
Name the four types of transplantation.
|
Autograft
Isograft Allograft Xenograft |
|
|
What are the three steps in primary graft rejection?
1) *** 2) *** 3) *** |
1) Revascularization
2) Cellular infiltration 3) Thrombosis & necrosis |
|
|
*** such as prednisone are potent anti-inflammatory agents.
|
Corticosteroids
|
|
|
***(abbrev. ***) is a fungal metabolite with immunosuppressive properties.
|
Cyclosporin A(CsA)
|
|
|
The 1st human kidney transplant(1935, Russia) failed due to ***.
|
bloodtype mismatch
|
|
|
1954, the 1st successful kidney transplant was performed in ***.
|
Boston
|
|
|
Graft rejections rate can vary... *** is rejected faster.
|
Skin
|
|
|
Both class I and II MHC antigens stimulate ***. Class I stimulates a *** response and Class II stimulates a *** response. Th cells ***.
|
antibody response
strong normal help generate antibody against class I&II MHC |
|
|
Graft Rejection:
Class I MHC antigens stimulate response from *** *** ***. Class II stimulate response from *** *** ***. Class *** MHC also stimulates B cells into plasma cells. |
CD8+ Tc cells
CD4+ T cells II |
|
|
Graft Rejection:
Th helps in what three ways? |
MHC antibody production
CD8 Tc cell response DTH |
|
|
Minor transplantation antigens are recognized by recipient’s *** *** in association with ***.
|
T- cells
self-MHC |
|
|
The immune response to tissue antigens encoded within the *** is the strongest force in rejection.
|
major histocompatibility complex
|
|
|
The process of graft rejection can be divided into a ***, in which *** cells are ***, and an ***, in which they attack the graph.
|
T - sensitization stage - stimulated
effector stage |
|
|
A major complication in bone marrow transplantation is ***, mediated by lymphocytes contained w/in the bone marrow.
|
graft-versus-host reaction
|
|
|
Monoclonal antibodies offer the possibility of specific immunosuppression by...
1) 2) |
1) deleting populations of reactive cells
2) inhibiting costimulatory signals leading to anergy in specifically reactive cells |
|
|
Antibodies like *** anti-thymocyte *** can be used to inhibit T cell function
... or monoclonal antibodies to T cell antigens like *** or ***. |
polyclonal anti-thymocyte globulins
CD3 or CD4 |
|
|
Name four commonly transplanted organs.
|
Cornea, lung
heart, liver bone marrow blood, skin |
|
|
Ch 16?
|
Tolerance and Autoimmunity
|
|
|
Ch 17?
|
Transplantation Immunology
|
|
|
Ch 18?
|
Immune Response to Infectious Diseases
|
|
|
Ch 19?
|
Vaccines
|
|
|
1/3) Allograft Rejection
Revascularization 1) Acceptance - *** 2) 1st set rejection 3) 2nd set rejection |
1) 3-7 days - revasculatization
2) 3-7 days 3) never days |
|
|
2/3) Allograft Rejection
Cellular Infiltration: 1) Acceptance - *** 2) 1st set rejection 3) 2nd set rejection |
1) 7-10 days - healing
2) 7-10 days 3) 3-4 days |
|
|
3/3) Allograft Rejection
Thrombosis & Necrosis 1) Acceptance - *** 2) 1st set rejection 3) 2nd set rejection |
1) 12-14 days - resolution
2) 10-14 days 3) 5-6 days |
|
|
CD4 T cells provide help for *** and *** *** cell response
. |
antibody
CD8 T |
|
|
Spell the main fungus based immunosuppressive drug.
|
ciclosporin
|
|
|
Spell the two secondary fungus based immunosuppressive drugs.
|
tacrolimus
sirolimus |
|
|
Spell the main corticosteroid drug.
|
prednisolone
|
|
|
Spell the main anti-mitosis immunosuppressive drug.
|
azathioprine
|
|
|
Spell the autoimmune neuromuscular disease.
|
myasthenia gravis
|
|
|
Spell SLE.
|
systemic lupus erythematosus
|
|
|
Spell the name of the 'borer body' parasite.
AKA? |
Schistosoma
blood-flukes |
|
|
Spell the name of the 'split body' parasite.
|
Trypanosoma
|
|
|
Name the parasite that causes skin sores.
|
Leishmaniasis
|
