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12 Cards in this Set
- Front
- Back
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*** are fully functional cells that can no longer divide.
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Terminally differentiated cells
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*** cancers are more frequenct than *** cancers.
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Sporadic
Familial |
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Sporadic retinoblastoma makes up ***%
Familiar retinoblastoma makes up ***% |
60%
40% |
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Oncogones - products normally ***
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stimulate cell proliferation
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Onco in latin means ***
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bulk, mass - tumor
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v-src
c-src |
viral oncogene
cellular oncogene |
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first 2 of 5 types of oncogenes
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growth factors
receptor and nonreceptor protein kinases |
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last 3 of 5 types of oncogenes
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receptors lacking protein kinase activity
cytoplasmic regulators nuclear transcription factors |
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Tumor suppressor genes require *** mutation.
Proto-oncogenes require *** mutation. |
2
1 |
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Retinoblastoma gene(pRB) is a ***.
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tumor suppresor
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*** are converted metabolically to active derivatives called ***.
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procarcinogens
ultimate carcinogens |
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Mutagenesis of carcinogens tested by ***.
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Ames test
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