Study your flashcards anywhere!

Download the official Cram app for free >

  • Shuffle
    Toggle On
    Toggle Off
  • Alphabetize
    Toggle On
    Toggle Off
  • Front First
    Toggle On
    Toggle Off
  • Both Sides
    Toggle On
    Toggle Off
  • Read
    Toggle On
    Toggle Off
Reading...
Front

How to study your flashcards.

Right/Left arrow keys: Navigate between flashcards.right arrow keyleft arrow key

Up/Down arrow keys: Flip the card between the front and back.down keyup key

H key: Show hint (3rd side).h key

A key: Read text to speech.a key

image

Play button

image

Play button

image

Progress

1/10

Click to flip

10 Cards in this Set

  • Front
  • Back
VIP

What are the six actions of heparin?
Actions of heparin:
1. inhibits the action of activated factor Xa and thrombin (factor IIa)
2. inhibits the action of several other serine protease enzymes (XIIa, XIa)
3. inhibits the aggregation of platelets (used in open heart surgery)
4. has a plasma clearing effect: turbid plasma is rapidly cleared of fat chylomicrons by a release of lipase from the blood vessel.
5. binds to vascular lining and neutralizes the postive charge
6. it causes a release of tissue factor pathway inhibitor
Can heparin be given orally?
No
VIP VIP VIP

What are the four endogenous modulators of heparin action (with out heparin won't work)?
1. AT-III (main heparin cofactor)
2. heparin cofactor II (secondary)
3. tissue factor pathway inhibitor (TFPI) - released by heparin to counteract tissue factor
4. platelet factor 4 (heparin neutralizing protein) - patient who has thrombocytosis, IPP, TTP
Describe heparin induced thrombocytopenia:
Generation of antiheparin platelet factor 4 antibodies. These antibodies activate platelts and endothelial cells
VIP

Protamine sulfate
This is a powerful heparin antagonist. It combines strongly with the acidic heparin to form a stable salt with loss of anticoagulant activity
What is the difference between low molecular weight heparins and high?
Low molecular weight heparins have a better cutaneous bioavailability, longer duration of action, less bleeding, and lesser thrombocytopenia
Three currently approved indications for low molecular weight heparins.
1. treatment of DVT
2. management of acute coronary syndromes
3. in surgical procedures
What are direct antithrombin-concentrates used for?
p.8 Heparin
What is HIRUDIN?
A protein from saliva of the medicinal leech that has been manufactored to excrete its anticoagulant effects and be used as anticoagulant management of heparin throbocytopenic patients.
What is ARGATROBAN?
A synthetic antithrombin agent that is currently used as an anticoagulant in patients who cannot be treated with heparin.