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39 Cards in this Set
- Front
- Back
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What are two chemicals that cause platelet aggregation?
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ADP
Thromboxane A2 |
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Two functions of thromboxane A2
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induces thrombogenesis
induces vasocontriction |
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Where is thromboxin A2 and serotonin 5-HT relased from?
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platelets
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What is the function of prostacyclin?
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inhibits thrombogenesis
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What are the affects of 5-HT in the vasculature?
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platelet aggregation
vasocontriction |
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Where do white thombi form?
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High pressure arterioles
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Forms in low pressure veins around a white thrombus and can detach to cause an embolus
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Red thrombus
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What is Virchow's triad?
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Hypercoaguability state
Venous Stasis Injury to endothelium |
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Vitamin K dependant factors
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2,7,9,10
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Contact activation factors
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11 and 12
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Thrombin sensitive factors
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5,8,13 and fibrinogen
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Inactivated clotting factors
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zymogens
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Catalyzes factor 7
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tissue factor
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Where is tissue factor found
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brain, lungs, kidney, liver
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Inhibits activated factor X
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Low molecular weight heparin
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Used to monitor the function of the extrensic system and common pathway
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Prothrombin time
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Measures the activity of the intrinsic system and common pathway
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Activated partial thromboplastin time
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Assesses the clotting of plasma by thrombin. What can affect it?
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Thrombin Time
Fibrinogen abnormalities |
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4 SE of heparin
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allergy
hair loss osteoporosis thrombocytopenia |
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How do you reverse heparin?
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Protamine sulfate
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Direct thrombin inhibitors that bind to active and inactive sites of thrombin
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hirudin
bivalirudin |
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Direct thrombin inhibitor that binds only to active thrombin sites
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Argatroban
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Direct thrombin inhibitor that can act on inactive fibrin bound thrombin in thrombi
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Hirudin
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During reversal of warfarin what three agents can be given?
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Vit K
FFP Factor IX |
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Has the longest half life of the fibrinolytics
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Tenecteplase
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IIb/IIIa receptor blocker
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abciximab
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Inhibits adenosine uptake and cGMP phopshodiesterase activity
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dipyridamole
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Competitively inhibits plasminogen activation
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aminocaproic acid
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Balances clotting and breaking down a clot
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endothelial cell wall
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What does VWF do?
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Causes recruitment of platelets
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Inactivate coagulation proteins
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Antiprotease
Antithrombin |
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Remodels thrombus in order to contain its size
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Plasmin
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Prevents clots from lysing (plasmin)
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Aminocaproic acid
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Drug that inhibits factor 10 and 2 equally
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Heparin
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Drug that inhibits factor 10 more often than factor 2
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Low Molecular weight heparin
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Drug that only inhibits factor 10
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Fondaparinux
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Two lab values needed to determine where clotting abnormality is occuring
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Bleeding time
Platelet count |
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Drug that inhibits thromboxane A 2
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Aspirin
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Drugs that inhibit ADP pathway
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Clopidogrel
Ticlidopine |
