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46 Cards in this Set
- Front
- Back
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cyclosporine mechanism
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binds cyclophilins
they inhibit calcineurin --> preventing production of IL-2 and its receptor --> block differentiation and activation of T cells |
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cyclosporine rx
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organ rejection after transplantation
some autoimmune |
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cyclosporine s/e's
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viral infections
lymphoma nephrotoxic (prevent c. mannitol diuresis) |
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tacrolimus is aka
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FK506
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FK506 is aka
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tacrolimus
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tacrolimus mechanism
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binds FK-binding protein
--> inhibiting secretion of IL-2 |
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tacrolimus rx
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organ transplant pts
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tacrolimus s/e's
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nephrotoxicity
peripheral neuropathy pleural effusion hypertension hyperglycemia |
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sirolimus is aka
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rapamycin
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rapamycin is aka
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sirolimus
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sirolimus moa
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binds mTOR
inhibits T-cell proliferation in response to IL-2 |
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sirolimus rx
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immunosuppression after kidney transplantation
in combo with cyclosporine and corticosteroids |
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sirolimus s/e's
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hyperlipidemia
thrombocytopenia leukopenia |
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daclizumab moa
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antibody against IL-2 receptor
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azathioprine moa
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precursor of 6-MP
toxic to proliferating lymphocytes |
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azathioprine rx
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kidney transplantation
autoimmune disorders (including glomerulonephritis, hemolytic anemia) |
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azathioprine s/e's
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bone marrow suppression
toxicity is ^ by allopurinol |
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muromonab-CD3 is aka
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OKT3
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OKT3 is aka
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muromonab-CD3
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muromonab moa
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binds to CD3 (epsilon chain) on T cells
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muromonab rx
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kidney transplantation
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drugs specifically listed for post kidney transplantation immunosuppression
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sirolimus
azathioprine muromonab daclizumab |
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muromonab s/e
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cytokine release syndrome
hypersensitivity |
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aldesleukin (IL-2)
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renal cell carcinoma
metastatic melanoma |
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a drug for renal cell carcinoma
& metastatic melanoma |
aldesleukin (IL-2)
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recombinant
G-CSF GM-CSF |
filgrastim
sargramostim |
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two drugs for recovery of bone marrow
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filgrastim
sargramostim |
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alpha-interferon
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Hep B and C
Kaposi's leukemias melanoma |
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beta-interferon
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multiple sclerosis
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gamma-interferon
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chronic granulomatous disease
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recombinant IL-11 is aka
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oprelvekin
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two drugs for thrombocytopenia
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oprelvekin (IL-11)
thrombopoietin |
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antibody against CD3
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muromonab
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antibody against IL-2
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daclizumab
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daclizumab rx
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prevent acute rejection of renal transplant
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antibodies against TNF-alpha
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infliximab
adalimumab |
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adalimumab is an Ab against
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TNF-alpha
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infliximab/adalimumab rx
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infliximab: CRAP
Crohn's rheumatoid arthritis ankylosing spondylitis psoriatic arthritis adalimumab: CRP |
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abciximab targets
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glycoprotein IIb/IIIa
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herceptin is aka
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trastuzumab
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abciximab rx (3)
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--cardiac ischemia
--unstable angina --percutaneous coronary intervention |
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trastuzumab targets
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erb-B2
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trastuzumab rx
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Her-2 breast cancer
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rituximab targets
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CD20
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what targets CD20?
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rituximab
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rituximab rx
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B-cell non-Hodgkin's lymphoma
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