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32 Cards in this Set
- Front
- Back
factor I
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fibrinogen
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factor II
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prothrombin
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factor III
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tissue factor
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factor IV
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calcium
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factor V
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labile factor
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factor VI
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"kein sechs"
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factor VII
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stable factor
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factor VIII
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anti-hemophilic factor
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factor IX
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Christmas factor (Hemophilia B)
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factor X
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Stuart-Prower factor
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factor XI
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plasma thromboplastin antecedent
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factor XII
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Hageman factor
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factor XIII
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fibrin stabilizing factor
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Von Willebrand Factor
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protects VIII from catabolism; made in endothelium and megakaryocytes
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vitamin K dependent factors; aka "the prothrombin group"
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II, VII, IX, X
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what 4 factors can cause prolongation of prothrombin time? which is most key?
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II, VII, IX, X; factor VII is key
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what system does the PT check?
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extrinsic ("WEPT")
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what system does the partial thromboplastin test check?
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intrinsic
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what are the 3 most common inherited coagulopathies?
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hemophilia A, hemophilia B, von Willebrand's
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what's the problem in von Willebrand's and which test is abnormal (PT or PTT)?
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poor platelet stickiness; both are normal; bleeding time is prolonged, though.
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in what coagulopathy is hemarthrosis of the knee most common?
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hemophilia A (A>B>vWB)
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what is most common presentation of vWB disease?
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menorrhagia
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what chemical increases vWB factor?
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vasopressin
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what causes hemophilia C?
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low factor XI (plasma thromboplastin antecedent)
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how does coumarin (warfarin) work?
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vitamin K analogue
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where does niacin come from?
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made from tryptophan, an essential aa
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where does serotonin come from?
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made from tryptophan
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what is carcinoid syndrome?
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too much serotonin made, not enough niacin --> pellagra
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what are pellagra symptoms?
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dermatitis, diearrhea, dementia, death
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what is Hartnup's disease?
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tryptophan malabsorption, so your body is "hardup" for tryptophan and niacin
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with what does anti-thrombin III complex?
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thrombin and factors IX, X, XI and XII
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how is the intrinsic system triggered?
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ruptured platelets and raw surface convert prekallikrein to kallikrein, which triggers factor XII to become XIIa
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