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32 Cards in this Set

  • Front
  • Back
factor I
fibrinogen
factor II
prothrombin
factor III
tissue factor
factor IV
calcium
factor V
labile factor
factor VI
"kein sechs"
factor VII
stable factor
factor VIII
anti-hemophilic factor
factor IX
Christmas factor (Hemophilia B)
factor X
Stuart-Prower factor
factor XI
plasma thromboplastin antecedent
factor XII
Hageman factor
factor XIII
fibrin stabilizing factor
Von Willebrand Factor
protects VIII from catabolism; made in endothelium and megakaryocytes
vitamin K dependent factors; aka "the prothrombin group"
II, VII, IX, X
what 4 factors can cause prolongation of prothrombin time? which is most key?
II, VII, IX, X; factor VII is key
what system does the PT check?
extrinsic ("WEPT")
what system does the partial thromboplastin test check?
intrinsic
what are the 3 most common inherited coagulopathies?
hemophilia A, hemophilia B, von Willebrand's
what's the problem in von Willebrand's and which test is abnormal (PT or PTT)?
poor platelet stickiness; both are normal; bleeding time is prolonged, though.
in what coagulopathy is hemarthrosis of the knee most common?
hemophilia A (A>B>vWB)
what is most common presentation of vWB disease?
menorrhagia
what chemical increases vWB factor?
vasopressin
what causes hemophilia C?
low factor XI (plasma thromboplastin antecedent)
how does coumarin (warfarin) work?
vitamin K analogue
where does niacin come from?
made from tryptophan, an essential aa
where does serotonin come from?
made from tryptophan
what is carcinoid syndrome?
too much serotonin made, not enough niacin --> pellagra
what are pellagra symptoms?
dermatitis, diearrhea, dementia, death
what is Hartnup's disease?
tryptophan malabsorption, so your body is "hardup" for tryptophan and niacin
with what does anti-thrombin III complex?
thrombin and factors IX, X, XI and XII
how is the intrinsic system triggered?
ruptured platelets and raw surface convert prekallikrein to kallikrein, which triggers factor XII to become XIIa