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26 Cards in this Set
- Front
- Back
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Crystallizes in Kidney
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Acyclovir
therefore you dose it based on Ideal weight and renal fxn |
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DOC for CNS, visceral and disseminated infections
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Acyclovir
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Acyclovir resistant VZV use?
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Foscarnet
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thymidine kinase intermediate
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Acyclovir
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Only PO, no HSV encephalitis and primary varicella and activated to pencyclovir
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FAmciclovir
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Only PO w/ better bioavailability d/t blood levels being 3-5x higher than w/ another drug in this family.
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Valcyclovir
Used as a step down therapy for acyclovir. IV acyclovir --> PO valcyclovir |
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tx of keratojuncitivitis
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trifluride
cannot be used systemically because it irreversibly inhibits thymidine synthase in both our DNA and viral DNA |
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acyclovir resistance
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1)virus decreases TK (virus gets smart and doesn't phosphorylize the prodrug)
2) altered DNA polymerase enzymes 3) altered substrate specificity |
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DOC for CMV
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Gancyclovir
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SE include: teratogenicity, carcinogenicity, mutagenicity.
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Ganciclovir
Valganciclovir (+ anemia and diarrhea) |
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Oral levels of this drug are equal to IV levels of Ganciclovir.
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Valgancyclovir (PO only)
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HSV and VZV resistance and directly inhibits DNA polymerase
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Foscarnet
2nd line CMV se: BMS, nephro and electrolyte disturbances. |
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Tx HSH and VZV and has a very long intracellular half life. You can give the pt one dose once a week.
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Cidofovir
SE: BMS, nephro, metabolic acidosis |
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Start this neuramidase inhibitor w/n 36 hrs of infection
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Oseltamivir (PO)
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Neuropsychiatric SE
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Oseltamivir
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Start this neuramidase inhibitor w/n 48 hrs of infection
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Zanamivir ( inhalation)
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Death caused by bronchospasms in asthmatics
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Zanamivir
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SE: flu like sxs for the 1st couple of days until the body acclimatizes
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Hep C- interferon products
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RSV
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palivizumab
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genital and plantar arts
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imiquimod
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inhibits GP41 Fusion
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Enfurvitide
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SE:mitochondrial toxicity and lipoatrophy
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NRTIs
combo: emtricitibine / tenofovir --> most highly recommended drug for HAART |
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HSN to this NRTI can be fatal
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Abacavir
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CNS effects
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Efavirenez (NNRTI)
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SE: dysglycemia + lipodystrophy + hepatotoxicity
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Protease inhibitors (atazanavir and darunavir)
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Integrase inhibitor
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raltegravir
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