Reading...
Play button
Play button
Use LEFT and RIGHT arrow keys to navigate between flashcards;
Use UP and DOWN arrow keys to flip the card;
H to show hint;
A reads text to speech;
26 Cards in this Set
- Front
- Back
|
Tears holes in fungal membrane by forming pores
|
Amphotericin B
|
|
|
IV only and can cause electrolytes abnoramality and renal failure.
|
AMphotericin B
|
|
|
must give your pts Na loading before and after tx with this antifungal
|
amphotericin B
|
|
|
which polyene has 2 subcategories of drugs that differ in the severity of their side effects?
|
Amphotericin B
classic- severe SE Liposomal- less severe SE |
|
|
SE: reiter, hypotension, fever, chills, pretreat w/ diphenhydramine and cannot cross BBB
|
Amphotericin B- probably Classic
|
|
|
Swish and spit for candidiasis
|
Nystatin
|
|
|
DOC for mucor mycosis
|
amphotericin B
|
|
|
inhibits fungal cytochrome P4503a and inhibits the enzyme that produces ergosterol from lanesterol
|
Azoles
|
|
|
causes gynecomastia
|
Ketoconazole
|
|
|
Resistance level from always to sometimes (C. krusei> C. glabrata > everything else)
|
Fluconazole
|
|
|
Used for ambulatory candida and crosses BBB
|
Fluconazole
|
|
|
DOC for basic candida albicans infections
|
Fluconazole
|
|
|
Used in combo w/ amphotericin B to cryptococcus neoformans in AIDs pts
|
Fluconazole
|
|
|
PO only, covers all Candida and is a potent CYP450 inhibitor
|
Itraconazole
|
|
|
Best azole for blasto and histo
|
Itraconazole
|
|
|
Increased death in heart failure pts
|
Itraconazole
|
|
|
DOC for invasive aspergillis
|
Voriconzole
|
|
|
IV and PO + visual disturbances as a SE
|
Voriconazole
|
|
|
Broadest spectrum azole + PO only
|
Posaconazole
|
|
|
in order for this drug to work optimally, it has to be taken with a high fat diet, like ice cream
|
Posaconazole
|
|
|
Primarily for onchyomycosis and athletes foot
|
Terbinafine
SE: GI and liver failure |
|
|
PO and topical against candida and dermatophytes (also candida resistant strains)
|
terbinafine
|
|
|
Essential to fungal cell wall integrity of aspergillus and candida
|
B-1,3 D glucan
|
|
|
IV only, hepatic excretion and asymptomatic bump in LFTs. No massive SE.
|
Echinocandins
Glucan synthesis inhibitors: caspofungin (clinical use: invasive aspergillus) micafungin andidula fungin |
|
|
mimics uracil
|
Flucytosine
|
|
|
Narrow therapeutic index drug, limited monotherapy use, usually paired w/ amphoterecin B for candidiasis, crypto, asp
|
Flucytosine
converted to 5-FU in fungal cell |
