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39 Cards in this Set
- Front
- Back
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Tx a pt for pseudomonas who is allergic to penicillins
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Aztreonam (except acinetobacter) IV, IM
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The cephalosporins that only cover gram +; tx for surgery prophylaxis and MSSE/MSSA
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Cefazolin (IV)
Cephalexin (PO) |
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Only cephalosporin generation w/ anaerobic activity
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2nd gen: cefotetan, cefoxitin
IV only- surgical pro; (+/-) |
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Sludging of the gall bladder
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ceftriaxone
(+/-) |
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Pseudomonal coverage, less effective, more broad - 3rd gen
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Ceftazidime IV
(+/-) |
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only PO 3rd gen cephalosporin
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Cefopodoxime
(+/-) |
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Only 4th gen cephalosporin
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Ceftepime IV
(+/-) + pseudomonas |
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used to tx enterococcus and lysteria by blocking glycosidic bonds and peptide bonds
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Vancomycin
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Narrow therapeutic index- must monitor trough
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Vancomycin
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Ototoxicity and nephrotoxicity = red man syndrome
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Vancomycin
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tx: C difficile
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Vancomycin (PO)
only pathogen that you tx w/ PO vanco |
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pt allergic to penicillin needs to tx her staph infections, what can she use?
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Vancomycin
no risk of cross-reactivity |
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Even though it covers gram positives, never ever use for HAP
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Daptomycin
Pulmonary surfactant disables it |
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Can tx VRE enterococcus, listeria by irreversibly inserting itself into the cell wall
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Daptomycin
as opposed to vanco who can only tx non vre enterococcus |
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fun Mnemonic : buy AT 30S, CCELL at 50S
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AT: Aminoglycosides and tetracyclines (30S )
CCELL: Chlormaphenicol, clindamycin, erythromycin, linomycin and linizid (at 50S) |
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Inhibits peptide bond formation and translocation; resistance= alternated target site and efflux pump.
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Macrolides
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DOC for chlamydia
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Azithromycin
IV, PO (gram + & some gram -) |
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Used to tx H. pylori; PO only
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Clarithromycin
(gram + & some gram -) |
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Able to bind 2 spots on the ribosomes; domains II and V
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Ketolidise (telithromycin)
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SE: diarrhea, visual changes; only indication is CAP
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Telithromycin
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similar coverage to macrolides w/ less resistance + SE: liver failure
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Telithromycin
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Highest risk for inducing C diff diarrhea
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Clindamycin
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good for anaerobes above the waste, identically similar to Macrolides MOA
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Clindamycin
differ: covers only + and anaerobes--> IV and PO. NO HA-MRSA, only CA-staph |
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Covers +, -, (including MRSA) and VRE and affects an earlier stage of synthesis (initiation)
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linezolid
IV, PO |
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SE: BMS, Serotinin syndrome
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Linezolid
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vancomycin resistance enterococcys faeciium drug
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Quinpristin- dalfopristin
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Prevents tRNA to mRNA w/ highest rate of resistance
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Tetracyclines
IV, PO |
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SE: tooth discoloration, failure to grow, photosensitivity
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Tetracyclines
d/t chelation w/ di and tri cations |
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PO, shorting acting, if left in the medicine cabinet past its expiration date it will decompose into a toxic product
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Tetracycline
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2nd line for CAP, COPD
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Doxycycline
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DOC for lyme dz, Q fever, Rocky mountain fever
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Doxycycline
IV and PO longer acting hepatic |
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30S; MOA identical to tetracycline. Only IV and covers -, + and anerobes
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Glycylcyclines
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Prevents efflux pumps by its long tail, cannot give to kids under 8, preggers or anyone breast feeding
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Glycylcyclines
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inhibits activity of peptidyltransferase (50S)
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Chloramphenicol
gray baby- glucuronidation |
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Causes misreading of codons and blocks translocation. 30S
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aminoglycosides
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Enters the cell via active transport which allows resistance to develop how?
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Aminoglycosides
by decreasing the permeability, the aminoglycosides cannot enter the cell |
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Narrow therapeutic Index- peaks and trough monitoring is recommended.
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Aminoglycosides (IV)
only works on aerobes |
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In aminoglycosides: peak shows _____ and trough shows ______
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peak- efficacy
trough- toxicity |
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1) tx: serratia marcescens
2) tx:Pseudomonas aeruginosa and acinetobacter 3) tx: resistant strains |
1) Gentamycin
2) Tobramycin 3) Amikacin |
