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44 Cards in this Set
- Front
- Back
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The effectors of the humoral branch are ***...
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antibodies
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What is the main difference between αβ and γδ
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αβ is specialized
γδ is general |
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CAMS work with what types of cells?
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leukocytes, monocytes, or granulocytes
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What is Central Tolerance?
*** mechanism that deletes *** clones if they posses receptors that ***. |
Primary
T/B-cell recognize self antigens |
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Antigen specific cells include *** CD8+Tcells and *** CD4+ Tcells that mediate the *** process.
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cytotoxic
cytokine secreting DTH |
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CAMs belong to these families of proteins...
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Selectins
Mucin-like CAMs Integrins Ig-superfamily CAMs(ICAMs) |
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What T-cell has the highest percentage of TCR V germline repertoire?
What percentage? |
αβ - Large
γδ - Small |
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TI-1 antigen provides *** signals.
TD antigen provides *** signals. |
both
one |
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Name a few organ specific autoimmune diseases in humans...
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spontaneous infertility
Addison's disease - adrenal cells Grave's disease - thyroid-stimulating hormone receptor |
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What T-cell has the highest percentage of CD8+?
What percentage? |
αβ - 30%
γδ - 30% |
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BCR tails have *** which produces effective intracellular signals.
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ITAM - Immunoreceptor tyrosine-based activation motif
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What T-cell has the highest percentage of CD4+CD8+?
What percentage? |
αβ - 1%
γδ - 1% |
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Allergy Skin Testing is done by *** of Allergens.
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Intradermal Injection
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What T-cell has the highest percentage of CD4-CD8-?
What percentage? |
αβ - 1%
γδ - 60% |
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Effector Responses can be divided into 2 types of responses:
1) Cells with ***. 2) subpopulation of *** that mediate ***. |
direct cytotoxic activity
CD4+ Tcells - DTH |
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What MHC restriction does the αβ T-cell have?
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CD4+ only w/MHC II
CD8+ only w/MHC I |
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Chemokines signal through receptors coupled with *** proteins.
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heterotrimeric large G
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What MHC restriction does the γδ T-cell have?
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none
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An allergen induces a *** response.
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humoral
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What ligand does the αβ T-cell use?
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MHC + peptide antigen
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IL-4 and IL-13 are type I hypersensitivity mediators that...
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Increase IgE production.
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What ligand does the γδ T-cell use?
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phospholipid
intact protein |
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Chemokines possess 4 conserved ***. Most of them fall into the two major subgroups ** and ***.
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cysteine residues
CC and CXC |
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*** have the greatest variety of chemokine receptors.
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Activated T lymphocytes
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Systemic lupus is a *** hypersensitive reaction.
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Type III
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CTL granules contain....
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Perforin
granzymes fragmentins |
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10% of lymphocyte cells migrate to extralymphoid tissues such as.....
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skin, mucosal epithelia of GI tract, pulmonary, and UT,
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What does HEV stand for?
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High endothelial venules
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Systemic Acute Phase Response causes *** to increase by up 1000 fold. This protein can bind to *** where it can then ***.
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C-reactive protein(CRP)
microorganisms active complement |
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*** is major chemokine for neutrophils
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IL-8
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Chromosome ***-alpha and delta chains
Chromosome ***-beta and gamma |
14
7 |
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Cytokines are formerly known as *** and ***.
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lymphokines
monokines |
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Name the principal cells that produce cytokines.
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Th cells
dendritic cells macrophages |
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Some plasma cells stay in the...
***(where they are produced) ***(short-lived) ***(short-lived) ***(---) |
lymphoid tissue
lymph node medulla sinusoids of spleen mucosal associated lymph tissue |
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Cytokine receptors initiate signals by tyrosine phosphorylation of *** by ***. This leads to the *** of STAT.
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STAT
JAK kinase (Janus-kinase family) dimerization |
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TI?
TD? |
Thymus-independent antigen
Thymus-dependent antigen |
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*** may play a role in regulating the intensity of the inflammatory response.
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Cytokine antagonists
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Name all types of cytokines
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autocrine
paracrine intracrine endocrine |
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Developing T-cells are known as ***.
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thymocytes
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About 48 hrs after activation T-cells enlarge into a *** cell and undergo repeated cell divisions.
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blast
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Only Tc gets the Ag presented on *** w/stabilization from ***.
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MHC I
CD8 |
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The *** is the main function of the humoral immune system?
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production of antibodies
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Only Th gets the Ag presented on *** w/stabilization from ***.
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MHCII
CD4 |
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The opposite of an epitope is...
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paratope
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