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38 Cards in this Set

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Occurs between 2 chromosomes over homologous base sequences

a.) Recombination
b.) Reassortment
c.) Complementation
d.) Phenotype Mixing
Recombination
Occurs only with segmented viral genomes.

a.) Recombination
b.) Reassortment
c.) Complementation
d.) Phenotype Mixing
Reassortment
Is the reason for the Influenza PANDEMIC.

a.) Recombination
b.) Reassortment
c.) Complementation
d.) Phenotype Mixing
Reassortment
Requires the mutation of (1 or 2) viruses making a NON-FUNCTIONAL PROTEIN.

a.) Recombination
b.) Reassortment
c.) Complementation
d.) Phenotype Mixing
Complementation

(another virus will come along and provide a non-mutated, functional protein for both viruses)
Requires SIMULTANEOUS viral infection

a.) Recombination
b.) Reassortment
c.) Complementation
d.) Phenotype Mixing
Phenotype Mixing
Formation of a PSEUDOVIRION which is Virus A coated with Virus B coating.

a.) Recombination
b.) Reassortment
c.) Complementation
d.) Phenotype Mixing
Phenotype mixing
Pseudovirion (virus A w/ virus B coating of surface proteins)

- Infectivity of Pseudovirion is determined by what?
- Progeny of Pseudovirion has the coating of what virus?
- Virus B coating (surface proteins)

- Virus A coat (in progeny)
VIRAL VACCINES

- Live attenuated viral vaccines elicit which type of mediated immunity?

- Do Live attenuated viral vaccines revert to virulence?
- Humoral immunity
- Cellular immunity

- Rarely reverts to virulence
VIRAL VACCINES

- Killed/Inactivated viral vaccines elicit which type of mediated immunity?

- Do Killed/Inactive viral vaccines revert to virulence?
- Humoral immunity only

- Never reverts to virulence
(always stable)
VIRAL VACCINES

- which vaccines do NOT require booster shots?
- Live-attenuated viral vaccines
VIRAL VACCINES

- Live attenuated viral vaccines are dangerous to give to whom?

- Exception?
- Immunocompromised patients
- Contacts of immunocompromised pts

- MMR can be given to HIV positive pts
VIRAL VACCINES

- List the Live-attenuated viral vaccines (x5)
("Live! 1 night only! See SMALL, YELLOW, CHICKENS get vaccinated by MMR. SABIN")

- Smallpox
- Yellow fever
- Chicken pox
- Sabin's Polio
- MMR
VIRAL VACCINES

- List the Killed/Inactivated viral vaccines. (x4)
(Killed = RIP Always)

- Rabies
- Influenza
- Polio (Salk)
- hepatitis A
What is a live-attenuated BACTERIAL vaccine
- BCG

(for TB)
VIRAL VACCINES

- what is a Live attenuated Polio vaccine?

- what is a Killed/Inactivated Polio vaccine?
(nick sabin is still alive)
- Sabin

(sal-"K"illed)
- Salk
VIRAL VACCINES

- what are the 2 recombinant viral vaccines?
- HBV

- HPV
VIRAL VACCINES

- recombinant hepatitis vaccine is which virus?

- what is recombinant?
- HBV

- HBsAg
VIRAL VACCINES

- recombinant HPV vaccine covers which papilloma types?
Types 6, 11, 16, and 18
What is the only Live-Attenuated Viral vaccine that you can give to HIV positive patients?
- MMR
All DNA viruses are dsDNA except?
- Parvoviridae (B19) is ssDNA
All DNA viruses are Linear except?
- Hepadnavirus (HBV) is partial circular

- Papilloma (HPV) is circular

- Polyoma (JC-PML) is circular
All RNA viruses are ssRNA except?
(Both belong to Reoviridae family:)

- Reovirus (colorado tick fever)
- Rotovirus (MCC of fatal diarrhea in kids)
Purified nucleic acids of most dsDNA are infectious except?
- Poxvirus

- HBV
Purified nucleic acids of which RNA viruses are infectious?
- Positive strand ssRNA ( = mRNA )
Purified nucleic acids of which RNA viruses are NOT infectious?

What do they use to become infectious?
- Negative strand ssRNA viruses
- dsRNA viruses (Rotovirus & Reovirus)

- enzymes
What are the Positive Strand RNA viruses? x7
("I went to RETRO TOGA party to drink FLAVored CORONA's and PICk up CALIfornia HEPE chicks")
- Retrovirus
- Togavirus
- Flavivirus
- Coronavirus
- Picornavirus
- Calicivirus
- Hepevirus
What are the Negative Strand RNA viruses? x7
(BAD PROF is always negative)
Bunyavirus
Arenavirus
Delta virus
Paramyxovirus
Rhabdovirus
Orthomyxovirus
Filovirus
All viruses are haploid (1 copy of RNA or DNA) except?
- Retrovirus

(Diploid = has 2 identical ssRNA)
All DNA viruses replicate ________, except _________, which replicates in the ___________.
Nucleus

Poxvirus

Cytoplasm
All RNA viruses replicate ________, except _________, which replicates in the ___________.
Cytoplasm

- Influenza virus (Negative RNA)
- Retrovirus (Positive RNA)

Nucleus
Enveloped viruses usually acquire their Envelops from ________, except for ________, which acquires from _______.
- Plasma membrane

- Herpesviridae

- Nuclear membrane
What are the Non-enveloped (Naked) viruses? x7
(Naked CPR & PAPP smear)
- Calicivirus
- Picornavirus
- Reovirus

- Parvovirus
- Adenovirus
- Papillomavirus
- Polyomavirus
List the DNA viruses (x7)
(HHAPPPP)

- Herpesvirus
- Hepadnevirus
- Adenovirus
- Parvovirus
- Papillomavirus
- Poxvirus
- Polyomavirus
INFLUENZA GENETICS

- cause of Pandemic Influenza
- cause of Epidemic Influenza
- which is more deadly?
- Genetic Shift (more deadly)

- Genetic Drift
INFLUENZA GENETICS

- Genetic SHIFT causes what type of influenza outbreak?

- Genetic SHIFT occurs via what process?

- give example
- Pandemic Influenza outbreak

- Reassortment (BOAR)

- Human flu A virus recombines with Swine flu A virus
INFLUENZA GENETICS

- Genetic DRIFT causes what type of Influenza outbreak?

- Genetic DRIFT occurs via what process?
- Epidemic Influenza outbreak

- Random mutation (antigenic drift)
INFLUENZA GENETICS

- how many negative stranded, linear RNA segments
8 segments
SEGMENTED GENOMES

- which viruses have segmented genomes?

- give number of genomes for each.
(BOAR)

- Bunyavirus (3) (also Circular)
- Orthomyxovirus (8)
- Arenavirus (2) (also Circular)
- Reovirus (10-12) (also DS & Double ICOS)