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38 Cards in this Set
- Front
- Back
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Occurs between 2 chromosomes over homologous base sequences
a.) Recombination b.) Reassortment c.) Complementation d.) Phenotype Mixing |
Recombination
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Occurs only with segmented viral genomes.
a.) Recombination b.) Reassortment c.) Complementation d.) Phenotype Mixing |
Reassortment
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Is the reason for the Influenza PANDEMIC.
a.) Recombination b.) Reassortment c.) Complementation d.) Phenotype Mixing |
Reassortment
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Requires the mutation of (1 or 2) viruses making a NON-FUNCTIONAL PROTEIN.
a.) Recombination b.) Reassortment c.) Complementation d.) Phenotype Mixing |
Complementation
(another virus will come along and provide a non-mutated, functional protein for both viruses) |
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Requires SIMULTANEOUS viral infection
a.) Recombination b.) Reassortment c.) Complementation d.) Phenotype Mixing |
Phenotype Mixing
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Formation of a PSEUDOVIRION which is Virus A coated with Virus B coating.
a.) Recombination b.) Reassortment c.) Complementation d.) Phenotype Mixing |
Phenotype mixing
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Pseudovirion (virus A w/ virus B coating of surface proteins)
- Infectivity of Pseudovirion is determined by what? - Progeny of Pseudovirion has the coating of what virus? |
- Virus B coating (surface proteins)
- Virus A coat (in progeny) |
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VIRAL VACCINES
- Live attenuated viral vaccines elicit which type of mediated immunity? - Do Live attenuated viral vaccines revert to virulence? |
- Humoral immunity
- Cellular immunity - Rarely reverts to virulence |
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VIRAL VACCINES
- Killed/Inactivated viral vaccines elicit which type of mediated immunity? - Do Killed/Inactive viral vaccines revert to virulence? |
- Humoral immunity only
- Never reverts to virulence (always stable) |
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VIRAL VACCINES
- which vaccines do NOT require booster shots? |
- Live-attenuated viral vaccines
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VIRAL VACCINES
- Live attenuated viral vaccines are dangerous to give to whom? - Exception? |
- Immunocompromised patients
- Contacts of immunocompromised pts - MMR can be given to HIV positive pts |
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VIRAL VACCINES
- List the Live-attenuated viral vaccines (x5) |
("Live! 1 night only! See SMALL, YELLOW, CHICKENS get vaccinated by MMR. SABIN")
- Smallpox - Yellow fever - Chicken pox - Sabin's Polio - MMR |
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VIRAL VACCINES
- List the Killed/Inactivated viral vaccines. (x4) |
(Killed = RIP Always)
- Rabies - Influenza - Polio (Salk) - hepatitis A |
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What is a live-attenuated BACTERIAL vaccine
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- BCG
(for TB) |
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VIRAL VACCINES
- what is a Live attenuated Polio vaccine? - what is a Killed/Inactivated Polio vaccine? |
(nick sabin is still alive)
- Sabin (sal-"K"illed) - Salk |
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VIRAL VACCINES
- what are the 2 recombinant viral vaccines? |
- HBV
- HPV |
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VIRAL VACCINES
- recombinant hepatitis vaccine is which virus? - what is recombinant? |
- HBV
- HBsAg |
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VIRAL VACCINES
- recombinant HPV vaccine covers which papilloma types? |
Types 6, 11, 16, and 18
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What is the only Live-Attenuated Viral vaccine that you can give to HIV positive patients?
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- MMR
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All DNA viruses are dsDNA except?
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- Parvoviridae (B19) is ssDNA
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All DNA viruses are Linear except?
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- Hepadnavirus (HBV) is partial circular
- Papilloma (HPV) is circular - Polyoma (JC-PML) is circular |
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All RNA viruses are ssRNA except?
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(Both belong to Reoviridae family:)
- Reovirus (colorado tick fever) - Rotovirus (MCC of fatal diarrhea in kids) |
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Purified nucleic acids of most dsDNA are infectious except?
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- Poxvirus
- HBV |
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Purified nucleic acids of which RNA viruses are infectious?
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- Positive strand ssRNA ( = mRNA )
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Purified nucleic acids of which RNA viruses are NOT infectious?
What do they use to become infectious? |
- Negative strand ssRNA viruses
- dsRNA viruses (Rotovirus & Reovirus) - enzymes |
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What are the Positive Strand RNA viruses? x7
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("I went to RETRO TOGA party to drink FLAVored CORONA's and PICk up CALIfornia HEPE chicks")
- Retrovirus - Togavirus - Flavivirus - Coronavirus - Picornavirus - Calicivirus - Hepevirus |
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What are the Negative Strand RNA viruses? x7
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(BAD PROF is always negative)
Bunyavirus Arenavirus Delta virus Paramyxovirus Rhabdovirus Orthomyxovirus Filovirus |
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All viruses are haploid (1 copy of RNA or DNA) except?
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- Retrovirus
(Diploid = has 2 identical ssRNA) |
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All DNA viruses replicate ________, except _________, which replicates in the ___________.
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Nucleus
Poxvirus Cytoplasm |
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All RNA viruses replicate ________, except _________, which replicates in the ___________.
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Cytoplasm
- Influenza virus (Negative RNA) - Retrovirus (Positive RNA) Nucleus |
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Enveloped viruses usually acquire their Envelops from ________, except for ________, which acquires from _______.
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- Plasma membrane
- Herpesviridae - Nuclear membrane |
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What are the Non-enveloped (Naked) viruses? x7
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(Naked CPR & PAPP smear)
- Calicivirus - Picornavirus - Reovirus - Parvovirus - Adenovirus - Papillomavirus - Polyomavirus |
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List the DNA viruses (x7)
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(HHAPPPP)
- Herpesvirus - Hepadnevirus - Adenovirus - Parvovirus - Papillomavirus - Poxvirus - Polyomavirus |
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INFLUENZA GENETICS
- cause of Pandemic Influenza - cause of Epidemic Influenza - which is more deadly? |
- Genetic Shift (more deadly)
- Genetic Drift |
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INFLUENZA GENETICS
- Genetic SHIFT causes what type of influenza outbreak? - Genetic SHIFT occurs via what process? - give example |
- Pandemic Influenza outbreak
- Reassortment (BOAR) - Human flu A virus recombines with Swine flu A virus |
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INFLUENZA GENETICS
- Genetic DRIFT causes what type of Influenza outbreak? - Genetic DRIFT occurs via what process? |
- Epidemic Influenza outbreak
- Random mutation (antigenic drift) |
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INFLUENZA GENETICS
- how many negative stranded, linear RNA segments |
8 segments
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SEGMENTED GENOMES
- which viruses have segmented genomes? - give number of genomes for each. |
(BOAR)
- Bunyavirus (3) (also Circular) - Orthomyxovirus (8) - Arenavirus (2) (also Circular) - Reovirus (10-12) (also DS & Double ICOS) |
