Xxx - Immunology (Anatomy)

Front 1

LYMPH NODE

- what are the 3 major anatomical parts of the LN?

Back 1

- Follicle
- Medulla
- Paracortex

Front 2

LYMPH NODE

- where do you find B-cells?
- where do you find T cells?
- where do you find Macrophages?

Back 2

- Follicle

- Paracortex

- Medullary Sinus

Front 3

LYMPH NODE

- Primary Follicle looks?
- Primary Follicle Lymphocyte activity?

Back 3

- Dense

- Dormant (Inactive) B-cells

Front 4

LYMPH NODE

- Secondary Follicle looks?
- Secondary Follicle Lymphocyte activity?

Back 4

- Pale Central Germinal Center

- Active B-cells

Front 5

LYMPH NODE

- Medullary Cord contains what cells?
- Medullary Sinus contains what cells?

Back 5

- Plasma Cells
(& closely packed lymphocytes)

- Macrophages
(& reticular cells)

Front 6

LYMPH NODE

- List 3 unique features of the Paracortex

Back 6

(P aracor T EX)

- Postcapillary venules (aka - HEV)

- T-cells

- EXtreme CMI response causes paracortex enlargement

Front 7

LYMPH NODE

- list it's basic functions x4

Back 7

- Nonspecific Filtration
(by Macrophages)

- Antibody production

- B-cell Storage & Activation
- T-cell Storage & Activation

Front 8

LYMPH NODE

- In DiGeorge syndrome, what changes are seen in LN?

Back 8

- Paracortex is not well developed

Front 9

SPLEEN (SINUSOIDS)

- what cells are found in the Red Pulp?
- what structures is found in Red Pulp?
(describe

Back 9

- RBCs

- Vascular channels
(with Fenestrated "Barrel Loop" BM)

Front 10

SPLEEN (SINUSOIDS)

- where are the T-cells found?
- where are the B-cells found?
- where are the Macrophages found?

Back 10

- White Pulp
- PALS
(Periarterial lymphatic sheath)

- Follicles (located in the White Pulp)

- near the fenestrated BM of the vascular channels (of the Red Pulp)

Front 11

LYMPH NODE

- how do T-cells & B-cells enter the LN?

Back 11

- via HEV (High Endothelial Venules)

(aka - Postcapillary venules)

Front 12

LYMPH NODE

- what structure is continuous with the EFFERENT lymphatics in the LN?

- what cells would you find there?

Back 12

- Medullary Sinus

- Macrophages

Front 13

SPLEEN (SINUSOIDS)

- What is the purpose of Macrophages in the spleen?

Back 13

- to remove ENCAPSULATED Bacteria

Front 14

SPLEEN (SINUSOIDS)

- Splenic dysfunction causes susceptibility to what TYPE of organisms?

- Describe the pathogenesis of Splenic Dysfunction in 3 steps.

Back 14

- Encapsulated Bacteria

Splenic Dysfunction
==> Decreased IgM
==> Decreased Complement activation
==> Decreased C3b Opsonization

(thus encapsulated bacteria susceptibility)

Front 15

THYMUS

- derived from what embryo structure?

Back 15

- 3rd Branchial POUCH

Front 16

THYMUS

- where are the Immature T-cells?
- where are the Mature T-cells?

Back 16

- Cortex of Thymus

- Medulla of Thymus

Front 17

THYMUS

- Lymphocytes are of what embyrological origin?

Back 17

- Mesenchymal tissue

Front 18

THYMUS

- what is the function of the Thymus?

Back 18

- T-cell Maturation

- T-cell Differentiation

Front 19

THYMUS

Cortex
- Description (& what cells there?)

Medulla
- Description (& what cells there?)

Back 19

- Dense
(Immature T-cells)

- Pale
(Mature T-cells)
(also has reticular cells)

Front 20

THYMUS

- Positive Selection is selection for?
- Negative Selection is selection for?

Back 20

- MHC I restriction

- High affinity for self
(nonreactivity to self)

Front 21

THYMUS

- Positive Selection occurs where?
- Negative Selection occurs where?

Back 21

- Cortex

- Medulla

Front 22

Hassal's Corpuscles

- are found where?

Back 22

- Medulla of Thymus

Front 23

PALS

- are found where?

Back 23

- Spleen White Pulp

Front 24

POST-SPLENECTOMY

- what 3 features are noted with patients post-splenectomy?

Back 24

- Howell Jolly Bodies
(nuclear remnants)

- Target cells

- Thrombocytosis
(lots of platelets)

Front 25

Primary LN Drainage

- Testes

Back 25

Superficial & Deep Plexus

(drains into the ................)

Para-Aortic LN

Front 26

Primary LN Drainage

- Scrotum

Back 26

- Superficial Inguinal LN

Front 27

Primary LN Drainage

- Superficial Inguinal LN drains what? (x3)

Back 27

- Anal canal (below Pectinate)

- Scrotum

- Superficial THIGH

Front 28

Primary LN Drainage

- Upper Limbs

Back 28

- Axillary LN

Front 29

Primary LN Drainage

- Lateral aspect of Boob

Back 29

- Axillary LN

Front 30

Primary LN Drainage

- Stomach

Back 30

- Celiac LN

Front 31

Primary LN Drainage

- Duodenum?
- Jejunum?

Back 31

- Superior Mesenteric LN

Front 32

Primary LN Drainage

- Sigmoid Colon

Back 32

Colic LN

(drains into the .........)

Inferior Mesenteric LN

Front 33

Primary LN Drainage

- Rectum (the Lower Part)

Back 33

- Internal Iliac LN

Front 34

Primary LN Drainage

- Anal Canal (above Pectinate)

- Anal Canal (below Pectinate)

Back 34

- Internal Iliac LN

- Superficial Inguinal LN

Front 35

Primary LN Drainage

- Para-aortic drains LN?

Back 35

- Testes

(via Superficial & Deep PLEXUS)

Front 36

Primary LN Drainage

- Popliteal LN drains what?

Back 36

Lateral Side of Foot Dorsum

Front 37

Primary LN Drainage

- RIGHT Lymphatic Duct drains what in the upper body?

- what drains everything else in the upper body?

Back 37

- Right Arm
- Right Half of Head

- Thoracic Duct

Front 38

Primary LN Drainage

- Thoracic Duct drains ?

Back 38

- Everything in the Upper Body except for right arm & right half of head